Analysis of risk factors for persistent gestational trophoblastic disease

Khoo, SK, Baartz, D, Sidhu, M, Yip, WL and Tripcony, L (2009) Analysis of risk factors for persistent gestational trophoblastic disease. Australian & New Zealand Journal of Obstetrics and Gynaecology, 49 6: 657-659. doi:10.1111/j.1479-828X.2009.01085.x


Author Khoo, SK
Baartz, D
Sidhu, M
Yip, WL
Tripcony, L
Title Analysis of risk factors for persistent gestational trophoblastic disease
Journal name Australian & New Zealand Journal of Obstetrics and Gynaecology   Check publisher's open access policy
ISSN 0004-8666
1479-828X
Publication date 2009-12
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1479-828X.2009.01085.x
Volume 49
Issue 6
Start page 657
End page 659
Total pages 3
Publisher John Wiley
Collection year 2010
Language eng
Subject C1
Formatted abstract
Setting: Persistent disease is a serious consequence of molar pregnancies. Its early detection is critical to effective chemotherapy. Therefore, determination of risk becomes an important clinical decision.

Objectives: To determine the relative risk of persistent disease in a cohort of patients with partial and complete molar pregnancies by analysis of five factors derived from a database using multivariate analysis.

Results: Of 686 patients, 78 developed persistent disease which required treatment (rate of 11.3%). Risk was markedly increased when serum human chorionic gonadotrophin (HCG) failed to reach negative by 12 weeks after evacuation [hazard ratio (HR) = 120.78, P < 0.001]. Risk was markedly decreased when the interval from last pregnancy exceeded 12 months (HR = 0.24, P = 0.005). Other factors such as patient's age, stage of gestation and serum HCG level at presentation were not found to be strongly associated with risk of persistent disease.

Conclusion: These findings support the application of the following two factors in risk prediction for molar pregnancies: > 12 weeks to become HCG negative and interval from last pregnancy < 12 months. They will contribute to a greater awareness of persistent disease and assist in early detection and effective chemotherapy.

Keyword gestational trophoblastic disease
persistent
risk factors
HUMAN CHORIONIC-GONADOTROPIN
COMPLETE MOLAR PREGNANCY
HYDATIDIFORM MOLE
HCG LEVELS
WOMEN
EVACUATION
NEOPLASIA
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Sun, 10 Jan 2010, 00:09:42 EST