Prehypertension: Epidemiology, consequences and treatment

Pimenta, Eduardo and Oparil, Suzanne (2010) Prehypertension: Epidemiology, consequences and treatment. Nature Reviews Nephrology, 6 1: 21-30. doi:10.1038/nrneph.2009.191

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Author Pimenta, Eduardo
Oparil, Suzanne
Title Prehypertension: Epidemiology, consequences and treatment
Journal name Nature Reviews Nephrology   Check publisher's open access policy
ISSN 1759-5061
Publication date 2010-01
Year available 2009
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrneph.2009.191
Volume 6
Issue 1
Start page 21
End page 30
Total pages 10
Place of publication London, UK
Publisher Nature Publishing Group
Collection year 2011
Language eng
Formatted abstract
The term prehypertension was coined in 1939 in the context of early studies that linked high blood pressure recorded during physical examination for life insurance purposes to subsequent morbidity and mortality. These studies demonstrated that individuals with blood pressure 120/80 mmHg, but 140/90 mmHgthe accepted value for the lower limit of the hypertensive rangehad an increased risk of hypertension, cardiovascular disease and early death from cardiovascular causes. The prehypertension classification of blood pressure was later used by the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure to define a group of individuals at increased risk of cardiovascular events because of elevated blood pressure, an increased burden of other risk factors such as obesity, diabetes mellitus, dyslipidemia, and inflammatory markers, and evidence of organ damage for example, microalbuminuria, retinal arteriolar narrowing, increased carotid arterial intima-media thickness, left ventricular hypertrophy and coronary artery disease. Nonpharmacological treatment with lifestyle modifications such as weight loss, dietary modification and increased physical activity is recommended for all patients with prehypertension as these approaches effectively reduce risk of cardiovascular events. Pharmacological therapy is indicated for some patients with prehypertension who have specific comorbidities, including diabetes mellitus, chronic kidney disease and coronary artery disease.
© 2010 Macmillan Publisher Limited. All rights reserved.
Keyword Blood pressure
Cardiovascular risk
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 17 November 2009

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 38 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 10 Jan 2010, 00:02:54 EST