Geographical genomics of human leukocyte gene expression variation in southern Morocco

Idaghdour, Youssef, Czika, Wendy, Shianna, Kevin V., Lee, Sang H., Visscher, Peter M., Martin, Hilary C., Miclaus, K, Jadallah, Sami J., Goldstein, David B., Wolfinger, Russell D. and Gibson, Greg (2010) Geographical genomics of human leukocyte gene expression variation in southern Morocco. Nature Genetics, 42 1: 62-67. doi:10.1038/ng.495

Author Idaghdour, Youssef
Czika, Wendy
Shianna, Kevin V.
Lee, Sang H.
Visscher, Peter M.
Martin, Hilary C.
Miclaus, K
Jadallah, Sami J.
Goldstein, David B.
Wolfinger, Russell D.
Gibson, Greg
Title Geographical genomics of human leukocyte gene expression variation in southern Morocco
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2010-01
Year available 2009
Sub-type Article (original research)
DOI 10.1038/ng.495
Volume 42
Issue 1
Start page 62
End page 67
Total pages 6
Editor Myles Axton
Place of publication New York, U.S.A.
Publisher Nature America Inc.
Collection year 2010
Language eng
Subject C1
0604 Genetics
970106 Expanding Knowledge in the Biological Sciences
Formatted abstract
Studies of the genetics of gene expression can identify expression SNPs (eSNPs) that explain variation in transcript abundance. Here we address the robustness of eSNP associations to environmental geography and population structure in a comparison of 194 Arab and Amazigh individuals from a city and two villages in southern Morocco. Gene expression differed between pairs of locations for up to a third of all transcripts, with notable enrichment of transcripts involved in ribosomal biosynthesis and oxidative phosphorylation. Robust associations were observed in the leukocyte samples: cis eSNPs (P < 10−08) were identified for 346 genes, and trans eSNPs (P < 10−11) for 10 genes. All of these associations were consistent both across the three sample locations and after controlling for ancestry and relatedness. No evidence of large-effect trans-acting mediators of the pervasive environmental influence was found; instead, genetic and environmental factors acted in a largely additive manner.
© 2010 Nature America, Inc. All rights reservsed.

Keyword Wide association
Norht Africa
Population structure
Complex disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 6 December 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
ERA 2012 Admin Only
School of Biological Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 72 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 76 times in Scopus Article | Citations
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Created: Sun, 10 Jan 2010, 00:02:48 EST