Mirabilins revisited:Polyketide alkaloids from a southern Australian marine sponge, Clathria sp.

El-Naggar, Mohamed, Conte, Melissa and Capon, Robert J. (2010) Mirabilins revisited:Polyketide alkaloids from a southern Australian marine sponge, Clathria sp.. Organic and Biomolecular Chemistry, 8 2: 407-412. doi:10.1039/b915624k


Author El-Naggar, Mohamed
Conte, Melissa
Capon, Robert J.
Title Mirabilins revisited:Polyketide alkaloids from a southern Australian marine sponge, Clathria sp.
Formatted title
Mirabilins revisited: Polyketide alkaloids from a southern Australian marine sponge, Clathria sp.

Journal name Organic and Biomolecular Chemistry   Check publisher's open access policy
ISSN 1477-0520
1477-0539
Publication date 2010
Sub-type Article (original research)
DOI 10.1039/b915624k
Open Access Status Not Open Access
Volume 8
Issue 2
Start page 407
End page 412
Total pages 6
Editor Richard Kelly
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2011
Language eng
Formatted abstract
Chemical investigation of a southern Australian marine sponge, Clathria sp., yielded the known mirabilins C, F and G, together with three new analogues, mirabilins H-J. For the first time mirabilins C and F are documented as the underivatized natural products, and a complete absolute stereochemistry is assigned to mirabilin F. Mirabilin I represents the first member of this structure class to incorporate a trans-fused ring junction. Structures for all mirabilins are assigned on the basis of detailed spectroscopic analysis. A plausible polyketide origin is proposed, linking all mirabilins and related sponge alkaloids. Mirabilin cytotoxicity against several human cancer cell lines is discussed.
© 2010 The Royal Society of Chemistry.
Keyword Tricyclic guanidine alkaloids
Ptilocaulin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Sun, 10 Jan 2010, 00:02:34 EST