Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patients

Liu, Y., Jiang, L., Cai, Q., Danoy, P., Barnardo, M. C. N. M., Brown, M. A. and Xu, H. (2010) Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patients. Tissue Antigens, 75 1: 61-64. doi:10.1111/j.1399-0039.2009.01379.x

Author Liu, Y.
Jiang, L.
Cai, Q.
Danoy, P.
Barnardo, M. C. N. M.
Brown, M. A.
Xu, H.
Title Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patients
Journal name Tissue Antigens   Check publisher's open access policy
ISSN 0001-2815
Publication date 2010-01
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1399-0039.2009.01379.x
Volume 75
Issue 1
Start page 61
End page 64
Total pages 4
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell Publishing
Collection year 2011
Language eng
Formatted abstract
The HLA-B27 subtypes have a varied racial and ethnic prevalence throughout the world. However, the association of B27-subtypes with ankylosing spondylitis (AS) in the mainland China is unknown. To determine the association of B27-subtypes with AS in the Mainland Chinese Han population, a total of unrelated 153 patients with AS were enrolled in a large case-control association study, and 1545 unrelated, healthy, ethnically matched blood donors were included as controls. The genotyping of B27 and its subtypes was performed using the polymerase chain reaction with sequence specific primers (PCR-SSP). A total of 130 (84.97%) AS patients and 61 (3.95%) healthy controls were B27 positive. Three B27-subtypes, B*2704, B*2705 and B*2710, were further identified, of which both B*2704 and B*2705 were strongly AS associated. B*2710 was only detected in one AS patient and two other healthy controls. Considering only B27-positive cases and controls, a statistically different frequency of B27-subtypes was observed, with an over-representation of B*2704 (P = 0.018). B*2704 was clearly more strongly associated than B*2705 with AS [odds ratio (OR) = 2.4, P = 0.011]. Furthermore, a combined analysis including three previous studies of B27-subtype distributions in Chinese AS cases confirmed the stronger association of B*2704 with AS than B*2705 (OR = 2.5, P = 0.00094).
© 2009 John Wiley & Sons A/S.
Keyword Ankylosing spondylitis
Association study
Chinese population
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 4 OCT 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 10 Jan 2010, 00:00:37 EST