Scabies: molecular perspectives and therapeutic implications in the face of emerging drug resistance

Mounsey, Kate E., Holt, Deborah C., McCarthy, James, Currie, Bart J. and Walton, Shelley F. (2008) Scabies: molecular perspectives and therapeutic implications in the face of emerging drug resistance. Future Microbiology, 3 1: 57-66. doi:10.2217/17460913.3.1.57


Author Mounsey, Kate E.
Holt, Deborah C.
McCarthy, James
Currie, Bart J.
Walton, Shelley F.
Title Scabies: molecular perspectives and therapeutic implications in the face of emerging drug resistance
Journal name Future Microbiology   Check publisher's open access policy
ISSN 1746-0913
1746-0921
Publication date 2008-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2217/17460913.3.1.57
Volume 3
Issue 1
Start page 57
End page 66
Total pages 10
Place of publication London, United Kingdom
Publisher Future Medicine
Language eng
Subject 11 Medical and Health Sciences
Abstract Limited effective treatments, coupled with recent observations of emerging drug resistance to oral ivermectin and 5% permethrin, raise concerns regarding the future control of scabies, especially in severe cases and in endemic areas where repeated community treatment programs are in place. There is consequently an urgent need to define molecular mechanisms of drug resistance in scabies mites and to develop and assess alternative therapeutic options, such as tea tree oil, in the event of increasing treatment failure. Molecular studies on scabies mites have, until recently, been restricted; however, recent advances are providing new insights into scabies mite biology and genetic mechanisms underlying drug resistance. These may assist in overcoming many of the current difficulties in monitoring treatment efficacy and allow the development of more sensitive tools for monitoring emerging resistance.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 36 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 45 times in Scopus Article | Citations
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Created: Fri, 08 Jan 2010, 11:49:17 EST by Ms Lynette Adams on behalf of School of Medicine