Post-transplant hepatosplenic T-cell lymphoma successfully treated with hyperCVAD regimen

Tey, Siok-Keen, Marlton, Paula V., Hawley, Carmel M., Norris, Debra and Gill, Devinder S. (2008) Post-transplant hepatosplenic T-cell lymphoma successfully treated with hyperCVAD regimen. American Journal of Hematology, 83 4: 330-333. doi:10.1002/ajh.21062

Author Tey, Siok-Keen
Marlton, Paula V.
Hawley, Carmel M.
Norris, Debra
Gill, Devinder S.
Title Post-transplant hepatosplenic T-cell lymphoma successfully treated with hyperCVAD regimen
Journal name American Journal of Hematology   Check publisher's open access policy
ISSN 0361-8609
Publication date 2008-04
Year available 2007
Sub-type Article (original research)
DOI 10.1002/ajh.21062
Volume 83
Issue 4
Start page 330
End page 333
Total pages 4
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Subject 1102 Cardiovascular Medicine and Haematology
Abstract Hepatosplenic T-cell lymphoma (HSTL) is an aggressive lymphoma. In post-transplant immunosuppressed patients, HSTL is usually rapidly fatal. We report successful treatment of post-transplant HSTL in a 50-year-old renal allograft recipient by reducing immunosuppression and using intensive chemotherapy consisting of alternating cycles of HyperCVAD (cyclophosphamide, vincristine, doxorubicin, and dexamethasone) and MTX/HiDAC (methotrexate, Ara-C). Remission is ongoing at 8+ years. Literature review identified another 20 cases of HSTL in solid organ transplant recipients: median survival was 4 months; no other patients survived beyond 12 months. Bone marrow involvement was universal, but changes were often subtle: 6 of 12 cases had nondiagnostic examinations earlier on. High index of suspicion may lead to more timely diagnosis of this uncommon form of post-transplant lymphoproliferative disorder, and treatment with intensive chemotherapy such as HyperCVAD may be curative. © 2007 Wiley-Liss, Inc.
Keyword Hepatosplenic T-cell lymphoma
HyperCVAD regimen
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published Online: 17 Sep 2007

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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