Unresolved issues in anthelmintic pharmacology for helminthiases of humans

Geary, Timothy G., Woo, Katherine, McCarthy, James S., Mackenzie, Charles D., Horton, John, Prichard, Roger K., de Silva, Nilanthi R., Olliaro, Piero L., Lazdins-Helds, Janis K., Engels, Dirk A. and Bundy, Donald A. (2010) Unresolved issues in anthelmintic pharmacology for helminthiases of humans. International Journal for Parasitology, 40 1: 1-13. doi:10.1016/j.ijpara.2009.11.001


Author Geary, Timothy G.
Woo, Katherine
McCarthy, James S.
Mackenzie, Charles D.
Horton, John
Prichard, Roger K.
de Silva, Nilanthi R.
Olliaro, Piero L.
Lazdins-Helds, Janis K.
Engels, Dirk A.
Bundy, Donald A.
Title Unresolved issues in anthelmintic pharmacology for helminthiases of humans
Journal name International Journal for Parasitology   Check publisher's open access policy
ISSN 0020-7519
1879-0135
Publication date 2010-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.ijpara.2009.11.001
Volume 40
Issue 1
Start page 1
End page 13
Total pages 13
Place of publication Oxford, United Kingdom
Publisher Elsevier
Collection year 2011
Language eng
Subject 11 Medical and Health Sciences
Abstract Helminth infections are an important constraint on the health and development of poor children and adults. Anthelmintic treatment programmes provide a safe and effective response, and increasing numbers of people are benefitting from these public health initiatives. Despite decades of clinical experience with anthelmintics for the treatment of human infections, relatively little is known about their clinical pharmacology. All of the drugs were developed initially in response to the considerable market for veterinary anthelmintics in high- and middle-income countries. In contrast, the greatest burden caused by these infections in humans is in resource-poor settings and as a result there has been insufficient commercial incentive to support studies on how these drugs work in humans, and how they should best be used in control programmes. The advent of mass drug administration programmes for the control of schistosomiasis, lymphatic filariasis, onchocerciasis and soil-transmitted helminthiases in humans increases the urgency to better understand and better monitor drug resistance, and to broaden the currently very narrow range of available anthelmintics. This provides fresh impetus for developing a comprehensive research platform designed to improve our understanding of these important drugs, in order to bring the scientific knowledge base supporting their use to a standard equivalent to that of drugs commonly used in developed countries. Furthermore, a better understanding of their clinical pharmacology will enable improved therapy and could contribute to the discovery of new products. © 2009 Australian Society for Parasitology Inc.
Keyword Anthelmintics
Schistosomiasis
Soil-transmitted helminths
Onchocerciasis
Lymphatic filariasis
Mass drug administration
Pharmacology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
Official 2011 Collection
School of Medicine Publications
 
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Created: Thu, 07 Jan 2010, 15:20:42 EST by Ms Lynette Adams on behalf of Queensland Institute of Medical Research