Depressive patients are more impulsive and inconsistent in intertemporal choice behavior for monetary gain and loss than healthy subjects--an analysis based on Tsallis' statistics

Takahashi, Taiki, Oono, Hidemi, Inoue, Takeshi, Boku, Shuken, Kako, Yuki, Kitaichi, Yuji, Kusumi, Ichiro, Masui, Takuya, Nakagawa, Shidn, Suzuki, Katsuji, Tanaka, Teruaki, Koyama, Tsukasa and Radford, Mark H. B. (2008) Depressive patients are more impulsive and inconsistent in intertemporal choice behavior for monetary gain and loss than healthy subjects--an analysis based on Tsallis' statistics. Neuroendocrinology Letters, 29 3: 351-358.

Author Takahashi, Taiki
Oono, Hidemi
Inoue, Takeshi
Boku, Shuken
Kako, Yuki
Kitaichi, Yuji
Kusumi, Ichiro
Masui, Takuya
Nakagawa, Shidn
Suzuki, Katsuji
Tanaka, Teruaki
Koyama, Tsukasa
Radford, Mark H. B.
Title Depressive patients are more impulsive and inconsistent in intertemporal choice behavior for monetary gain and loss than healthy subjects--an analysis based on Tsallis' statistics
Journal name Neuroendocrinology Letters   Check publisher's open access policy
ISSN 0172-780X
Publication date 2008
Sub-type Article (original research)
Open Access Status
Volume 29
Issue 3
Start page 351
End page 358
Total pages 8
Place of publication Stockholm Sweden
Publisher Maghira & Maas Publications
Language eng
Subject 1117 Public Health and Health Services
Formatted abstract
OBJECTIVES:
Depression has been associated with impaired neural processing of reward and punishment. However, to date, little is known regarding the relationship between depression and intertemporal choice (delay discounting) for gain and loss. This examination is potentially important for advances in neuroeconomics of intertemporal choice, because depression is associated with reduced serotonergic activities in the brain.

DESIGN AND SETTING:
We compared impulsivity and inconsistency in intertemporal choice for monetary gain and loss between depressive patients and healthy control subjects.

METHODS:
We conducted delay discounting tasks for gain and loss in depressed and healthy control subjects. We then quantified impulsivity and inconsistency in the delay discounting with parameters in the q-exponential discount function based on Tsallis’ statistics.

RESULTS:
We observed that depressive patients were more impulsive and time-inconsistent in intertemporal choice action for gain and loss, in comparison to healthy controls. MAIN

FINDINGS:

Depressed patients were more irrational in temporal discounting.

CONCLUSIONS:

The usefulness of the q-exponential discount function for assessing the impaired decision-making by depressive patients was demonstrated. Furthermore, biophysical mechanisms underlying the altered intertemporal choice by depressive patients are discussed in relation to impaired serotonergic neural systems.
Keyword depression
discounting
neuroeconomics
impulsivity
inconsistency
Tsallis' statistics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Thu, 07 Jan 2010, 13:38:49 EST by Ms Lynette Adams on behalf of School of Medicine