Clinician response to Candida organisms in the urine of patients attending hospital

Chen, S. C. A., Tong, Z. S., Lee, O. C., Halliday, C., Playford, E. G., Widmer, F., Kong, F. R., Wu, C. and Sorrell, T. C. (2008) Clinician response to Candida organisms in the urine of patients attending hospital. European Journal of Clinical Microbiology and Infectious Diseases, 27 3: 201-208. doi:10.1007/s10096-007-0427-9


Author Chen, S. C. A.
Tong, Z. S.
Lee, O. C.
Halliday, C.
Playford, E. G.
Widmer, F.
Kong, F. R.
Wu, C.
Sorrell, T. C.
Title Clinician response to Candida organisms in the urine of patients attending hospital
Journal name European Journal of Clinical Microbiology and Infectious Diseases   Check publisher's open access policy
ISSN 0934-9723
1435-4373
Publication date 2008-03
Sub-type Article (original research)
DOI 10.1007/s10096-007-0427-9
Volume 27
Issue 3
Start page 201
End page 208
Total pages 8
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Subject 11 Medical and Health Sciences
1103 Clinical Sciences
06 Biological Sciences
0605 Microbiology
Abstract The epidemiology of 54 episodes of candiduria with respect to clinical risk factors, species of Candida and physician response to the isolation of Candida in urine were studied in an observational survey over 3 months. Candida spp. were isolated from 4.7% of positive urine cultures. Common predisposing conditions included antibiotic use (74.1%), urinary drainage devices (57.4%), surgery (51.9%), intensive care unit (ICU) or high-dependency care unit (HDU) admission (42.6%) and urinary tract (UT) disease (18.5%). Upper UT infection was uncommon (n = 3). Of 65 Candida isolates, C. albicans predominated (85.2%), followed by C. glabrata (27.8%) and other Candida spp. (6.2%). All isolates were susceptible to fluconazole, itraconazole, voriconazole, amphotericin and caspofungin. Indwelling urinary catheters were removed in 76.2% of episodes. Antifungal therapy was initiated in 33.3% of cases independently of patient symptoms, underlying disease or Candida colony count. Patients in ICU/HDUs were significantly more likely to receive antifungal agents than those outside these units (p  < 0.001). Fluconazole was the most common drug prescribed (77.8%). Clearance of candiduria occurred independently of antifungal therapy (p = 0.60). Physicians often did not follow up a positive urine result for Candida. Efforts to increase clinician awareness of current recommendations for managing candiduria and further study to elucidate specific risk factors in defined patient populations are warranted.
Keyword Candida-albicans infection
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published online: 4 December 2007

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Thu, 07 Jan 2010, 12:58:22 EST by Ms May Balasaize on behalf of Faculty Of Health Sciences