ATP-binding cassette transporters in Escherichia coli

Moussatova, Anastassiia, Kandt, Christian, O'Mara, Megan L. and Tieleman, D. Peter (2008) ATP-binding cassette transporters in Escherichia coli. BBA: Biomembranes, 1778 9: 1757-1771. doi:10.1016/j.bbamem.2008.06.009


Author Moussatova, Anastassiia
Kandt, Christian
O'Mara, Megan L.
Tieleman, D. Peter
Title ATP-binding cassette transporters in Escherichia coli
Formatted title
ATP-binding cassette transporters in Escherichia coli
Journal name BBA: Biomembranes   Check publisher's open access policy
ISSN 0005-2736
Publication date 2008-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.bbamem.2008.06.009
Volume 1778
Issue 9
Start page 1757
End page 1771
Total pages 15
Place of publication Amsterdam, The Netherlands
Publisher Elseiver B.V.
Language eng
Subject 0605 Microbiology
Abstract ATP-binding cassette (ABC) transporters are integral membrane proteins that actively transport molecules across cell membranes. In Escherichia coli they consist primarily of import systems that involve in addition to the ABC transporter itself a substrate binding protein and outer membrane receptors or porins, and a number of transporters with varied functions. Recent crystal structures of a number of ATPase domains, substrate binding proteins, and full-length transporters have given new insight in the molecular basis of transport. Bioinformatics approaches allow an approximate identification of all ABC transporters in E. coli and their relation to other known transporters. Computational approaches involving modeling and simulation are beginning to yield insight into the dynamics of the transporters. We summarize the function of the known ABC transporters in E. coli and mechanistic insights from structural and computational studies. © 2008 Elsevier B.V. All rights reserved.
Keyword ABC transporter
Homology
Periplasmic binding protein
BtuCD
Simulation
Importer
P-glycoprotein
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Issue title: Structural proteomics of the cell envelope of Gram-negative bacteria, edited by D.P. Tieleman

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
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