Long-term follow-up after tight control of blood pressure in type 2 diabetes

Holman, Rury R., Paul, Sanjoy K., Bethel, M. Angelyn, Neil, H. Andrew W. and Matthews, David R. (2008) Long-term follow-up after tight control of blood pressure in type 2 diabetes. New England Journal of Medicine, 359 15: 1565-1576. doi:10.1056/NEJMoa0806359

Author Holman, Rury R.
Paul, Sanjoy K.
Bethel, M. Angelyn
Neil, H. Andrew W.
Matthews, David R.
Title Long-term follow-up after tight control of blood pressure in type 2 diabetes
Journal name New England Journal of Medicine   Check publisher's open access policy
ISSN 1533-4406
Publication date 2008-09-09
Sub-type Article (original research)
DOI 10.1056/NEJMoa0806359
Volume 359
Issue 15
Start page 1565
End page 1576
Total pages 12
Place of publication Boston, MA, United States
Publisher Massachusetts Medical Society
Language eng
Subject 1117 Public Health and Health Services
Formatted abstract
Post-trial monitoring of patients in the United Kingdom Prospective Diabetes Study (UKPDS) examined whether risk reductions for microvascular and macrovascular disease, achieved with the use of improved blood-pressure control during the trial, would be sustained.

Among 5102 UKPDS patients with newly diagnosed type 2 diabetes mellitus, we randomly assigned, over a 4-year period beginning in 1987, 1148 patients with hypertension to tight or less-tight blood-pressure control regimens. The 884 patients who underwent post-trial monitoring were asked to attend annual UKPDS clinics for the first 5 years, but no attempt was made to maintain their previously assigned therapies. Annual questionnaires completed by patients and general practitioners were used to follow patients who were unable to attend the clinic in years 1 through 5, and questionnaires were used for all patients in years 6 to 10. Seven prespecified aggregate clinical end points were examined on an intention-to-treat basis, according to the previous randomization categories.


Differences in blood pressure between the two groups during the trial disappeared within 2 years after termination of the trial. Significant relative risk reductions found during the trial for any diabetes-related end point, diabetes-related death, microvascular disease, and stroke in the group receiving tight, as compared with less tight, blood-pressure control were not sustained during the post-trial follow-up. No risk reductions were seen during or after the trial for myocardial infarction or death from any cause, but a risk reduction for peripheral vascular disease associated with tight blood-pressure control became significant (P=0.02).

The benefits of previously improved blood-pressure control were not sustained when between-group differences in blood pressure were lost. Early improvement in blood-pressure control in patients with both type 2 diabetes and hypertension was associated with a reduced risk of complications, but it appears that good blood-pressure control must be continued if the benefits are to be maintained. (UKPDS 81; Current Controlled Trials number, ISRCTN75451837 [controlled-trials.com] .)

Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
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Created: Thu, 07 Jan 2010, 10:24:48 EST by Ms Lynette Adams on behalf of School of Public Health