Impact of comorbid diabetes on quality of life and perception of angina pain in people with angina registered with general practitioners in the UK

Stone, M. A., Khunti, K., Squire, I. and Paul, S. (2008) Impact of comorbid diabetes on quality of life and perception of angina pain in people with angina registered with general practitioners in the UK. Quality of Life Research, 17 6: 887-894. doi:10.1007/s11136-008-9363-0


Author Stone, M. A.
Khunti, K.
Squire, I.
Paul, S.
Title Impact of comorbid diabetes on quality of life and perception of angina pain in people with angina registered with general practitioners in the UK
Journal name Quality of Life Research   Check publisher's open access policy
ISSN 0962-9343
1573-2649
Publication date 2008-08
Sub-type Article (original research)
DOI 10.1007/s11136-008-9363-0
Volume 17
Issue 6
Start page 887
End page 894
Total pages 8
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Language eng
Subject 1117 Public Health and Health Services
Formatted abstract
Aims
To investigate the impact of comorbid diabetes on general and angina-related quality of life (QoL) in people with angina.

Methods
We analysed data for a subset of patients with angina, from a randomised controlled trial conducted in UK primary care. SF36 scores and Seattle Angina Questionnaire scores were compared for people with and without diabetes. We adopted a robust statistical approach, using nonparametric quantile regression to adjust for the influence of potential confounders.

Results
Data were available for 904 cases of whom 181 (20%) had diabetes. Presence of comorbid diabetes was significantly associated with reduced generic QoL for all SF36 domains and Seattle Angina Questionnaire physical limitation scores (estimated regression coefficient −12.33), but not for the other angina-related scores. Greater frequency of perceived angina was strongly correlated with reduced QoL (P < 0.001) and angina frequency was similar in people with and without diabetes (P = 0.576).

Conclusions
Our results confirm the cumulative impact of having multiple chronic diseases on QoL. Though limited by the data available, our finding of similar angina frequency in patients with and without diabetes contributes to the debate regarding the influence of autonomic neuropathy on perception of angina in people with diabetes.
Keyword Angina pectoris
Diabetes mellitus
Quality of life
Autonomic neuropathy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Thu, 07 Jan 2010, 09:58:48 EST by Jon Swabey on behalf of Faculty Of Health Sciences