Abnormalities in cardiac baroreceptor sensitivity in acute ischaemic stroke patients are related to aortic stiffness

Eveson, David J., Robinson, Thompson G., Shah, Nainal S., Panerai, Ronney B., Paul, Sanjoy K. and Potter, John F. (2005) Abnormalities in cardiac baroreceptor sensitivity in acute ischaemic stroke patients are related to aortic stiffness. Clinical Science, 108 5: 441-447.


Author Eveson, David J.
Robinson, Thompson G.
Shah, Nainal S.
Panerai, Ronney B.
Paul, Sanjoy K.
Potter, John F.
Title Abnormalities in cardiac baroreceptor sensitivity in acute ischaemic stroke patients are related to aortic stiffness
Journal name Clinical Science   Check publisher's open access policy
ISSN 0143-5221
1470-8736
0144-9664
Publication date 2005-05
Sub-type Article (original research)
DOI 10.1042/CS20040264
Volume 108
Issue 5
Start page 441
End page 447
Total pages 7
Place of publication London, U.K.
Publisher Portland Press
Language eng
Subject 1102 Cardiovascular Medicine and Haematology
Formatted abstract Cardiac BRS (baroreceptor reflex sensitivity) is impaired following ischaemic stroke and predicts the risk of subsequent long-term death and disability. Impaired cardiac BRS may be due to impaired central processing of baroreceptor information following stroke or reduced baroreceptor activity due to increased large artery stiffness. We evaluated the relationship between large (aortic) artery stiffness and cardiac BRS during the acute phase of ischaemic stroke and in comparison with a group of stroke-free control subjects. Thirty-one ischaemic stroke patients were studied within 48 h of onset and again on day 14, along with 26 control subjects free of cerebrovascular disease. Cardiac BRS (determined by spectral analyses) and arterial stiffness estimated by PWVcf (carotid–femoral pulse wave velocity) using applanation tonometry were obtained. At baseline, cardiac BRS was lower in the stroke compared with the control group (4.3±2.3 compared with 6.5±4.2 ms/mmHg; P<0.05). Cardiac BRS values were correlated with PWVcf at <48 h (r=-0.51, P<0.01) and on day 14 (r=-0.54, P<0.01), but not in the control group (r=-0.27, P=not significant). In quantile regression models, taking into account the effect of all cardiovascular variables, cardiac BRS was independently related to PWVcf at baseline and on day 14 in the stroke patients, but stroke was not related to cardiac BRS level when other cardiovascular variables were considered. Wall stiffness of the arterial vessels involved in the baroreflex arc may account for, at least in part, the reduced cardiac BRS observed in acute stroke patients. © 2005 The Biochemical Society
Keyword Arterial stiffness
Autonomic nervous system
Baroreceptor sensitivity
Cerebrovascular disorder
Elasticity
Pressoreceptor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Population Health Publications
 
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