Anticonvulsant profile of a balanced ketogenic diet in acute mouse seizure models

Samala, Ramakrishna, Willis, Sarah and Borges, Karin (2008) Anticonvulsant profile of a balanced ketogenic diet in acute mouse seizure models. Epilepsy Research, 81 2-3: 119-127. doi:10.1016/j.eplepsyres.2008.05.001


Author Samala, Ramakrishna
Willis, Sarah
Borges, Karin
Title Anticonvulsant profile of a balanced ketogenic diet in acute mouse seizure models
Journal name Epilepsy Research   Check publisher's open access policy
ISSN 0920-1211
1872-6844
Publication date 2008-10
Sub-type Article (original research)
DOI 10.1016/j.eplepsyres.2008.05.001
Volume 81
Issue 2-3
Start page 119
End page 127
Total pages 9
Place of publication Amsterdam, Holland
Publisher Elsevier
Language eng
Subject 06 Biological Sciences
Abstract Anticonvulsant effects of the ketogenic diet (KD) have been reported in the mouse, although previous studies did not control for intake of vitamins, minerals and antioxidants. The aim of this study was to examine the effects of balanced ketogenic and control diets in acute mouse seizure models. The behavior in four mouse seizure models, plasma d-β-hydroxybutyrate (d-BHB) and glucose levels were determined after feeding control diet, 4:1 and 6:1 KDs with matched vitamins, minerals and antioxidants. Feeding 4:1 and 6:1 KDs ad lib to 3-week-old (adolescent) mice resulted in 1.2–2.2 mM d-BHB in plasma, but did not consistently change glucose levels. The 6:1 KD reproducibly elevated the CC50 (current that initiates seizures in 50% mice tested) in the 6-Hz model after 14 days of feeding to adolescent CD1 mice. Higher plasma d-BHB levels correlated with anticonvulsant effects. Despite ketosis, no consistent anticonvulsant effects of KDs were found in the fluorothyl or pentylenetetrazole CD1 mouse models. The 4:1 KD was neither anticonvulsant nor neuroprotective in hippocampus in the C3H mouse kainate model. Taken together, the KD's anticonvulsant effect was limited to the 6-Hz model, required chronic feeding with 6:1 fat content, and was independent from lowering plasma glucose.
Keyword Kainate
Fluorothyl
Pentylenetetrazole
6-Hz model
β-Hydroxybutyrate
Glucose
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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