Sensitivity of respiratory bacteria to lignocaine

Chandan, Snehal S., Faoagali, Joan and Wainwright, Claire E. (2005) Sensitivity of respiratory bacteria to lignocaine. Pathology, 37 4: 305-307. doi:10.1080/00313020500168752

Author Chandan, Snehal S.
Faoagali, Joan
Wainwright, Claire E.
Title Sensitivity of respiratory bacteria to lignocaine
Journal name Pathology   Check publisher's open access policy
ISSN 0031-3025
Publication date 2005-08
Sub-type Article (original research)
DOI 10.1080/00313020500168752
Volume 37
Issue 4
Start page 305
End page 307
Total pages 3
Place of publication Abingdon, United Kingdom
Publisher Informa Healthcare
Language eng
Subject 1103 Clinical Sciences
Formatted abstract
Lignocaine, a topical anaesthetic agent, is generally used in variable concentrations usually between 2% and 4% on the vocal cords prior to flexible bronchoscopy and bronchoalveolar lavage (BAL) procedures. The aim of this study was to investigate whether 2% or 1% lignocaine significantly inhibits the growth of organisms commonly found in the respiratory tract, in particular Streptococcus pneumoniae.

In order to determine the antibiotic effect of lignocaine on lower respiratory tract flora, five different organisms were examined in vitro using well diffusion, disc diffusion and microbroth dilution against 1% and 2% concentrations of lignocaine.

Antimicrobial activity could not be detected using the well diffusion and the disc diffusion methods, as lignocaine failed to diffuse through the media. The microbroth dilution method showed reproducible bactericidal effect of these respiratory isolates against Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae at 2% concentration. Lignocaine 2% showed no growth inhibition against Pseudomonas aeruginosa and Candida albicans. Lignocaine 1% also partially inhibited S. pneumoniae.

As lignocaine shows significant inhibition of respiratory pathogens such as Streptococcus pneumoniae even at a concentration of 1%, the lowest concentration possible should be used for flexible bronchoscopy and BAL to maximise the chance of recovery of these organisms. (author abstract)
Keyword Lignocaine
Streptococcus pneumoniae
Bronchoalveolar lavage
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Created: Tue, 05 Jan 2010, 12:14:21 EST by Jon Swabey on behalf of School of Medicine