HIV and malaria co-infection: Interactions and consequences of chemotherapy

Skinner-Adams, T. S., McCarthy, J. S., Gardiner, D. L. and Andrews, K. T. (2008) HIV and malaria co-infection: Interactions and consequences of chemotherapy. Trends in Parasitology, 24 6: 264-271. doi:10.1016/

Author Skinner-Adams, T. S.
McCarthy, J. S.
Gardiner, D. L.
Andrews, K. T.
Title HIV and malaria co-infection: Interactions and consequences of chemotherapy
Journal name Trends in Parasitology   Check publisher's open access policy
ISSN 1471-4922
Publication date 2008-06-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/
Volume 24
Issue 6
Start page 264
End page 271
Total pages 8
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2008
Language eng
Subject 1112 Oncology and Carcinogenesis
111205 Chemotherapy
11 Medical and Health Sciences
1117 Public Health and Health Services
Abstract The global epidemiology of HIV/AIDS and malaria overlap because a significant number of HIV-infected individuals live in regions with different levels of malaria transmission. Although the consequences of co-infection with HIV and malaria parasites are not fully understood, available evidence suggests that the infections act synergistically and together result in worse outcomes. The importance of understanding chemotherapeutic interactions during malaria and HIV co-infection is now being recognized. We know that some antimalarial drugs have weak antiretroviral effects; however, recent studies have also demonstrated that certain antiretroviral agents can inhibit malaria-parasite growth. Here, we discuss recent findings on the impact of HIV/AIDS and malaria co-infection and the possible roles of chemotherapy in improving the treatment of these diseases.
Keyword Malaria Parasite
Malaria Transmission
HIV/ Aids and malaria overlap
Chemotherapeutic interactions
Antimalarial drugs
Antiretroviral effects
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Created: Mon, 04 Jan 2010, 10:10:38 EST by Rosalind Blair on behalf of Faculty Of Health Sciences