Altered clot kinetics in patients with non-alcoholic fatty liver disease

Hickman, I. J., Sullivan, C. M., Flight, S., Campbell, C., Crawford, D. H., Masci, P. P., O'Moore-Sullivan, T. M., Prins, J. B. and Macdonald, G. A. (2009) Altered clot kinetics in patients with non-alcoholic fatty liver disease. Annals of Hepatology, 8 4: 331-338.


Author Hickman, I. J.
Sullivan, C. M.
Flight, S.
Campbell, C.
Crawford, D. H.
Masci, P. P.
O'Moore-Sullivan, T. M.
Prins, J. B.
Macdonald, G. A.
Title Altered clot kinetics in patients with non-alcoholic fatty liver disease
Journal name Annals of Hepatology   Check publisher's open access policy
ISSN 1665-2681
Publication date 2009-10
Year available 2009
Sub-type Article (original research)
Volume 8
Issue 4
Start page 331
End page 338
Total pages 8
Editor Sanchez, N. H.
Place of publication Mexico
Publisher Sociedad Mexicana de Hepatologia
Collection year 2010
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
110307 Gastroenterology and Hepatology
Abstract Background. Emerging evidence has linked the presence of non-alcoholic fatty liver disease (NAFLD) with an increased risk for cardiovascular events. We hypothesised that altered clot kinetics and platelet function may contribute to this increased risk. This study compared whole blood clotting kinetics in patients with 1) non-cirrhotic NAFLD (n = 28) and 2) healthy control subjects (n = 22). Methods. Clotting kinetics were assessed in whole Wood using thromboelastography (TEG) and assessed for correlations with cardiovascular risk factors. Results. Clot kinetics in patients with NAFLD showed significantly stronger clot development (maximum amplitude (MA); 58.3 6.3 mm vs. 52.0 10.1 mm, p = 0.01) and reduced clot lysis in the presence of thrombin (35 30% vs. 51 26% clot lysis 30 minutes after MA, p = 0.03) compared to control subjects. Clot strength was independently positively associated with body mass index in NAFLD, but not in control subjects. There was a greater platelet contribution to clot strength in patients with NAFLD compared to controls despite similar platelet counts. There was no association between clot kinetics and features of the metabolic syndrome or presence of type 2 diabetes. Conclusion. Patients with NAFLD have disturbances in ex-vivo clot kinetics including increased clot strength and clots that are more resistant to thrombin-stimulated lysis
Keyword Obesity
Platelets
Thrombosis
Chronic liver disease
NASH
Thromboelastography
HOMEOSTASIS MODEL ASSESSMENT
TYPE-2 DIABETIC-PATIENTS
ARTERY WALL THICKNESS
INSULIN-RESISTANCE
ENDOTHELIAL DYSFUNCTION
CARDIOVASCULAR-DISEASE
CYCLIC-NUCLEOTIDES
HEPATIC STEATOSIS
PLATELET-FUNCTION
ADIPOSE-TISSUE
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Sun, 27 Dec 2009, 00:05:43 EST