The use of acetic acid in magnification chromocolonoscopy for pit pattern analysis of small polyps

Togashi, K., Hewett, D. G., Whitaker, D. A., Hume, G. E., Francis, L. and Appleyard, M. N. (2006) The use of acetic acid in magnification chromocolonoscopy for pit pattern analysis of small polyps. Endoscopy, 38 6: 613-616. doi:10.1055/s-2006-925001

Author Togashi, K.
Hewett, D. G.
Whitaker, D. A.
Hume, G. E.
Francis, L.
Appleyard, M. N.
Title The use of acetic acid in magnification chromocolonoscopy for pit pattern analysis of small polyps
Journal name Endoscopy   Check publisher's open access policy
ISSN 0013-726X
Publication date 2006-06
Sub-type Article (original research)
DOI 10.1055/s-2006-925001
Volume 38
Issue 6
Start page 613
End page 616
Total pages 4
Place of publication Stuttgart, Germany
Publisher Georg Thieme Verlag
Language eng
Subject 1112 Oncology and Carcinogenesis
Formatted abstract
Background and Study Aims:
The role of acetic acid spray during magnification chromocolonoscopy has not previously been evaluated. We aimed to compare the accuracy of predicting polyp histology at magnification colonoscopy, using acetic acid and indigo carmine, either alone or in combination.

Patients and Methods:
A total of 46 consecutive patients with polyps detected during colonoscopy which measured 10 mm or less were alternately divided into two groups. In group A patients, 1.5 % acetic acid was applied to the mucosa first, followed by indigo carmine spray; in group B patients, the order was reversed. The pit pattern was assessed after application, in real time. All the lesions were resected and examined histologically.

Altogether, 37 adenomas and 36 hyperplastic polyps were evaluated. In group A, the diagnostic accuracy after spraying with acetic acid was 95 %, which increased to 98 % after application of indigo carmine. In group B, the accuracy after indigo carmine application was 83 %. After subsequent spraying with acetic acid, images were enhanced in 70 % of patients, with an increase in accuracy to 97 %. The mean time required to obtain an initial clear image with the first dye was 14 seconds for both groups.

This is the first description of the use of acetic acid for pit pattern analysis of colonic polyps. Its ease of use, low cost, and safety, together with its excellent accuracy in the assessment of polyp pit patterns suggest that this method could easily be applied to routine magnification colonoscopy.

Keyword Acetic acid
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 24 Dec 2009, 08:48:50 EST by Elissa Saffery on behalf of Faculty Of Health Sciences