Adenocarcinoma of the gastroesophageal junction: Influence of esophageal resection margin and operative approach on outcome

Barbour, Andrew P., Rizk, Nabil P., Gonen, Mithat, Tang, Laura, Bains, Manjit S., Rusch, Valerie W., Coit, Daniel G. and Brennan, Murray F. (2007) Adenocarcinoma of the gastroesophageal junction: Influence of esophageal resection margin and operative approach on outcome. Annals of Surgery, 246 1: 1-8. doi:10.1097/01.sla.0000255563.65157.d2


Author Barbour, Andrew P.
Rizk, Nabil P.
Gonen, Mithat
Tang, Laura
Bains, Manjit S.
Rusch, Valerie W.
Coit, Daniel G.
Brennan, Murray F.
Title Adenocarcinoma of the gastroesophageal junction: Influence of esophageal resection margin and operative approach on outcome
Journal name Annals of Surgery   Check publisher's open access policy
ISSN 0003-4932
1528-1140
Publication date 2007-07
Sub-type Article (original research)
DOI 10.1097/01.sla.0000255563.65157.d2
Volume 246
Issue 1
Start page 1
End page 8
Total pages 8
Place of publication Philadelphia, U.S.A.
Publisher Lippincott Willams & Wilkins
Language eng
Subject 1112 Oncology and Carcinogenesis
Formatted abstract Objective:
To determine whether the length of esophageal resection or the operative approach influences outcome for patients with adenocarcinoma of the gastroesophageal junction (GEJ).

Summary Background Data: 
While R0 resection remains the mainstay of curative treatment of patients with GEJ cancer, the optimal length of esophageal resection remains controversial.

Methods:
Patients with Siewert I, II, or III adenocarcinoma who underwent complete gross resection without neoadjuvant therapy were identified from a prospectively maintained database. Proximal margin lengths were recorded ex vivo as the distance from the gross tumor edge to the esophageal transection line. Operative approaches were grouped into gastrectomy (limited esophagectomy) or esophagectomy (extended esophagectomy).

Results:
From 1985 through 2003, 505 patients underwent R0/R1 gastrectomy (n = 153) or esophagectomy (n = 352) without neoadjuvant treatment. There were no differences in R1 resection rate, number of nodes examined or operative mortality between gastrectomy and esophagectomy. Univariate analysis found >3.8 cm to be the ex vivo proximal margin length (approximately 5 cm in situ) most predictive of improved survival. Multivariable analysis in patients who underwent R0 resection with ≥15 lymph nodes examined (n = 275) found the number of positive lymph nodes, T stage, tumor grade, and ex vivo proximal margin length >3.8 cm to be independent prognostic factors. Subset analysis found that the benefit associated with >3.8 cm margin was limited to patients with T2 or greater tumors and ≤6 positive lymph nodes.

Conclusions:
In patients not receiving neoadjuvant therapy, the goal for patients with adenocarcinoma of the GEJ should be R0 resection including at least 15 lymph nodes, preferably with 5 cm of grossly normal in situ proximal esophagus for those with ≤6 positive lymph nodes. The operative approach may be individualized to achieve these goals.
Keyword Adenocarcinoma
Esophageal resection
Gastroesophageal junction
GEJ
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 71 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 78 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Access Statistics: 114 Abstract Views  -  Detailed Statistics
Created: Wed, 23 Dec 2009, 14:43:11 EST by Elissa Saffery on behalf of Faculty Of Health Sciences