Cleansing lotion containing tamarind fruit pulp extract. II. Study of cumulative irritation effects in human

Maenthaisong, Ratree, Viyoch, Jarupa, Chaiyakunapruk, Nathorn and Warnnissorn, Prateep (2007) Cleansing lotion containing tamarind fruit pulp extract. II. Study of cumulative irritation effects in human. Journal of Cosmetic Dermatology, 6 3: 178-182. doi:10.1111/j.1473-2165.2007.00328.x


Author Maenthaisong, Ratree
Viyoch, Jarupa
Chaiyakunapruk, Nathorn
Warnnissorn, Prateep
Title Cleansing lotion containing tamarind fruit pulp extract. II. Study of cumulative irritation effects in human
Journal name Journal of Cosmetic Dermatology   Check publisher's open access policy
ISSN 1473-2165
1473-2130
Publication date 2007-09
Sub-type Article (original research)
DOI 10.1111/j.1473-2165.2007.00328.x
Volume 6
Issue 3
Start page 178
End page 182
Total pages 5
Place of publication Oxford, England
Publisher Wiley-Blackwell
Language eng
Subject 11 Medical and Health Sciences
1117 Public Health and Health Services
Formatted abstract
Background
Cleansing lotion containing extract of tamarind fruit pulp was developed to provide skin a lighter effect. Skin irritation may occur due to keratolytic effect of α-hydroxyl acids (AHA) in the tamarind fruit pulp extract.

Objective
To assess the cumulative irritation effect of cleansing lotion containing tamarind fruit extract with 2% (w/w) tartaric acid on human skin compared with placebo product and de-ionized water.

Methods

The study design was a single-blinded, randomized side of arm, and controlled study. Three samples, including test product, placebo product, and de-ionized water, were repeatedly applied on the inner forearm of 15 healthy females (aged 28.3 ± 3.1 years) for 30 min daily for 5 days under semi-occlusive patch. Skin irritation was measured by using visual scoring and instruments such as Tewameter® and Mexameter®. All measurements were done before application of samples every day from day 1 until day 5. Final measurements were done after the last application for 3 days (day 8).

Results

The results obtained from the visual scoring scale indicated no irritation signs and symptoms of test product. Mean differences of transepidermal water loss and erythema values between test product and de-ionized water and between test and placebo products were not statistically significant (P > 0.05).

Conclusions

These findings indicate a preliminary safety evidence of our developed cleansing lotion containing the natural AHAs and can be used as cumulative evidence for supporting the future home use study of this product in human.
Keyword α-hydroxyl acids
cleansing lotion
clinical trial
irritation
tamarind
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Wed, 23 Dec 2009, 14:09:53 EST by Ms Lynette Adams on behalf of School of Public Health