Aberrant trafficking of transmembrane proteins in human disease

Cobbold, Christian, Monaco, Anthony P., Sivaprasadarao, Asipu and Ponnambalam, Sreenivasan (2003) Aberrant trafficking of transmembrane proteins in human disease. Trends in Cell Biology, 13 12: 639-647.


Author Cobbold, Christian
Monaco, Anthony P.
Sivaprasadarao, Asipu
Ponnambalam, Sreenivasan
Title Aberrant trafficking of transmembrane proteins in human disease
Journal name Trends in Cell Biology   Check publisher's open access policy
ISSN 0962-8924
1879-3088
Publication date 2003-12
Year available 2003
Sub-type Article (original research)
DOI 10.1016/j.tcb.2003.10.008
Volume 13
Issue 12
Start page 639
End page 647
Total pages 9
Place of publication Cambridge
Publisher Elsevier Trends Journals.
Language eng
Subject 06 Biological Sciences
0601 Biochemistry and Cell Biology
11 Medical and Health Sciences
1101 Medical Biochemistry and Metabolomics
Abstract Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, transporters and metabolic enzymes. In this review, we focus on the current understanding of trafficking of mutant membrane proteins in human disease and speculate on therapeutic strategies.
Keyword Transmembrane
Proteins
TMD
GPCR
G-protein coupled receptors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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