Angina Symptoms Are Associated With Mortality in Older Women With Ischemic Heart Disease

Berecki-Gisolf, J, Humphreyes-Reid, L, Wilson, A and Dobson, A (2009) Angina Symptoms Are Associated With Mortality in Older Women With Ischemic Heart Disease. Circulation, 120 23: 2330-2336. doi:10.1161/CIRCULATIONAHA.109.887380

Author Berecki-Gisolf, J
Humphreyes-Reid, L
Wilson, A
Dobson, A
Title Angina Symptoms Are Associated With Mortality in Older Women With Ischemic Heart Disease
Journal name Circulation   Check publisher's open access policy
ISSN 0009-7322
Publication date 2009-12-08
Year available 2009
Sub-type Article (original research)
DOI 10.1161/CIRCULATIONAHA.109.887380
Volume 120
Issue 23
Start page 2330
End page 2336
Total pages 7
Editor Joseph Loscalzo
Place of publication United States
Publisher Lippincott Williams & Wilkins
Collection year 2010
Language eng
Subject C1
110201 Cardiology (incl. Cardiovascular Diseases)
920103 Cardiovascular System and Diseases
920507 Women's Health
Formatted abstract
Background.  Angina symptoms have been reported to predict mortality in men. The aim of this study was to investigate the association between angina symptoms and mortality in women.
Methods and Results.  In 2004, 873 older participants in the Australian Longitudinal Study on Women’s Health with self-reported ischemic heart disease participated in a nested substudy. Women were 77 to 83 years of age; 165 (19%) died during the 4.5-year follow-up. Angina symptoms were established with Seattle Angina Questionnaire (SAQ) scores for physical limitation, angina frequency, angina stability, and disease perception. Proportional hazards modeling was used to examine the relationship of SAQ score differences with mortality. Physical limitation scores were associated with mortality, with hazard ratios of 1.1, 1.9, and 3.4 for mild, moderate, and severe versus minimal limitations, respectively (P<0.001). Angina frequency scores were also associated with death, with hazard ratios of 1.2, 1.2, and 4.8 for mild, moderate, and severe versus minimal angina frequency, respectively (P<0.001). Age (hazard ratio 1.1, 95% confidence interval 1.0 to 1.2), pulmonary disease (hazard ratio 1.6, 95% confidence interval 1.2 to 2.3), and kidney disease (hazard ratio 1.7, 95% confidence interval 1.1 to 2.5) were statistically significantly associated with mortality in a multivariable model of clinical predictors. In a combined model with SAQ scores and clinical predictors, SAQ scores for physical limitation and angina stability remained statistically significantly associated with mortality.
Conclusions.  In older women with ischemic heart disease, angina symptoms assessed by use of SAQ scores for physical limitations and angina frequency were associated with mortality; SAQ scores may therefore prove to be a useful tool for risk assessment in this patient group.

Keyword angina
coronary disease
Q-Index Code C1
Q-Index Status Confirmed Code

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Created: Sun, 20 Dec 2009, 00:04:21 EST