Familial correlations in postmenopausal serum concentrations of sex steroid hormones and other mitogens: A twins and sisters study

Stone, Jennifer, Folkerd, Elizabeth, Doody, Deborah, Schroen, Chris, Treloar, Susan A., Giles, Graham G., Pike, Malcolm C., English, Dallas R., Southey, Melissa C., Hopper, John L. and Dowsett, Mitch (2009) Familial correlations in postmenopausal serum concentrations of sex steroid hormones and other mitogens: A twins and sisters study. Journal of Clinical Endocrinology & Metabolism, 94 12: 4793-4800. doi:10.1210/jc.2009-0713


Author Stone, Jennifer
Folkerd, Elizabeth
Doody, Deborah
Schroen, Chris
Treloar, Susan A.
Giles, Graham G.
Pike, Malcolm C.
English, Dallas R.
Southey, Melissa C.
Hopper, John L.
Dowsett, Mitch
Title Familial correlations in postmenopausal serum concentrations of sex steroid hormones and other mitogens: A twins and sisters study
Journal name Journal of Clinical Endocrinology & Metabolism   Check publisher's open access policy
ISSN 0021-972X
Publication date 2009-12
Sub-type Article (original research)
DOI 10.1210/jc.2009-0713
Volume 94
Issue 12
Start page 4793
End page 4800
Total pages 8
Place of publication Chevy Chase, Maryland, U.S.A.
Publisher The Endocrine Society
Language eng
Subject 110306 Endocrinology
1103 Clinical Sciences
Formatted abstract

Background: Serum concentrations of some hormones are risk factors for certain cancers, but little is known about their familial associations especially for females.

Methods: We measured serum concentrations of estradiol (E2), testosterone (T), SHBG, prolactin, and IGF-I for 645 Australian female postmenopausal twins and their sisters [182 monozygotic (MZ) and 107 dizygotic (DZ) pairs and 67 nontwin sisters] using well-established immunoassays. After suitable transformation and adjusting for age, body mass index (BMI), and time since menopause, familial correlations and proportions of variance attributed to genetic (h2) and nongenetic factors common to sisterships (c2) were estimated under the classic twin multivariate normal model using FISHER.

Results: For all serum concentrations except prolactin, MZ, DZ, and sister pairs were correlated (P < 0.001). MZ correlations were in the range 0.5–0.7, and for all serum concentrations, there were no differences between DZ and sister correlations. MZ correlations were greater than DZ and sister correlations for log SHBG (P = 0.0001), IGF-I (P = 0.0002), and square-root T (P = 0.007) but not log E2 (P = 0.3), and the respective h2 estimates were 0.56 (SE = 0.14), 0.53 (0.17), 0.39 (0.14), and 0.14 (0.16). For log E2 and square-root T, c2 estimates were 0.39 (0.14) and 0.22 (0.12).

Conclusion: There are strong familial correlations in postmenopausal SHBG, IGF-I, and to a lesser extent T, which are consistent with a genetic etiology. For E2, and to a lesser extent T, correlations are consistent with substantial nongenetic familial factors. The latter might include maternal effects.

Keyword Breast-cancer Risk
Adult male twins
IGF-I
Pedigree Analysis
Androgen excess
Women
Questionnaire
Prolactin
Zygosity
Premenopausal
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Sun, 20 Dec 2009, 00:02:24 EST