Suppression of polyploidy by the BRCA2 protein

Sagulenko, Evgeny, Savelyeva, Larissa, Ehemann, Volker, Sagulenko, Vitaliya, Hofmann, Wera, Arnold, Katrin, Claas, Andreas, Scherneck, Siegfried and Schwab, Manfred (2007) Suppression of polyploidy by the BRCA2 protein. Cancer Letters, 257 1: 65-72. doi:10.1016/j.canlet.2007.07.003

Author Sagulenko, Evgeny
Savelyeva, Larissa
Ehemann, Volker
Sagulenko, Vitaliya
Hofmann, Wera
Arnold, Katrin
Claas, Andreas
Scherneck, Siegfried
Schwab, Manfred
Title Suppression of polyploidy by the BRCA2 protein
Journal name Cancer Letters   Check publisher's open access policy
ISSN 0304-3835
Publication date 2007-11-08
Sub-type Article (original research)
DOI 10.1016/j.canlet.2007.07.003
Volume 257
Issue 1
Start page 65
End page 72
Total pages 8
Editor M. Schwab
Place of publication Amsterdam, Netherlands
Publisher Elsevier Ireland
Language eng
Subject 0304 Medicinal and Biomolecular Chemistry
1112 Oncology and Carcinogenesis
Formatted abstract
Mounting evidence implicates BRCA2 not only in maintenance of genome integrity but also in cell-cycle checkpoints. However, the contribution of BRCA2 in the checkpoints is still far from being understood. Here, we demonstrate that breast cancer cells MX-1 are unable to maintain genome integrity, which results in gross polyploidization. We generated MX-1 clones, stably expressing BRCA2, and found that BRCA2 acts to suppress polyploidy. Compared with MX-1, the ectopically BRCA2-expressing cells had different intracellular levels of Aurora A, Aurora B, p21, E2F-1, and pRb, suggesting a BRCA2-mediated suppression of polyploidy via stabilization of the checkpoint proteins levels.
© 2007 Elsevier Ireland Ltd. All rights reserved.
Keyword BRCA2
Cell-cycle checkpoint
Breast cancer
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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