An overview of the sensory receptors regulating cough

Mazzone, Stuart B. (2005) An overview of the sensory receptors regulating cough. Cough, 1 2: 2-1-2-9. doi:10.1186/1745-9974-1-2

Author Mazzone, Stuart B.
Title An overview of the sensory receptors regulating cough
Journal name Cough   Check publisher's open access policy
ISSN 1745-9974
Publication date 2005-08
Sub-type Article (original research)
DOI 10.1186/1745-9974-1-2
Open Access Status DOI
Volume 1
Issue 2
Start page 2-1
End page 2-9
Total pages 9
Place of publication London, United Kingdom
Publisher Biomed Central
Language eng
Subject 06 Biological Sciences
0601 Biochemistry and Cell Biology
Abstract The cough reflex represents a primary defensive mechanism for airway protection in a variety of mammalian species. However, excessive and inappropriate coughing can emerge as a primary presenting symptom of many airway diseases. Cough disorders are characterized by a reduction in the threshold for reflex initiation and, as a consequence, the occurrence of cough in response to stimuli that are normally innocuous in nature. The current therapeutic strategies for the treatment of cough disorders are only moderately effective. This undoubtedly relates in part to limitations in our understanding of the neural components comprising the cough reflex pathway. The aim of this review is to provide an overview of current concepts relating to the sensory innervation to the mammalian airways, focusing particularly on the sensory receptors that regulate cough. In addition, the review will highlight particular areas and issues relating to cough neurobiology that are creating controversy in the field.
Keyword Cough Receptor
Rapidly Adapting Receptor
Q-Index Code C1
Additional Notes Article no. 2, August 2005

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
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Created: Fri, 18 Dec 2009, 14:32:59 EST by Ms Lynette Adams on behalf of Faculty of Science