Changes in serum adiponectin concentrations in critical illness: a preliminary investigation

Venkatesh, Bala, Hickman, Ingrid, Nisbet, Janelle, Cohen, Jeremy and Prins, John (2009) Changes in serum adiponectin concentrations in critical illness: a preliminary investigation. Critical Care, 13 4: R105.1-R105.5. doi:10.1186/cc7941

Author Venkatesh, Bala
Hickman, Ingrid
Nisbet, Janelle
Cohen, Jeremy
Prins, John
Title Changes in serum adiponectin concentrations in critical illness: a preliminary investigation
Journal name Critical Care   Check publisher's open access policy
ISSN 1466-609X
Publication date 2009-07-02
Year available 2009
Sub-type Article (original research)
DOI 10.1186/cc7941
Open Access Status DOI
Volume 13
Issue 4
Start page R105.1
End page R105.5
Total pages 5
Editor Jean-Louis Vincent
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2010
Language eng
Subject C1
920299 Health and Support Services not elsewhere classified
110310 Intensive Care
110299 Cardiovascular Medicine and Haematology not elsewhere classified
Formatted abstract
Adiponectin plays an important role in the regulation of tissue inflammation and insulin sensitivity. Perturbations in adiponectin concentration have been associated with obesity and the metabolic syndrome. Data on adiponectin pathophysiology in critical illness are limited.


Twenty three critically ill patients (9 severe sepsis, 7 burns, 7 trauma). Adiponectin assays on Days 3 (D3) and 7 (D7). Simultaneous, cortisol, cortisone and CRP measurements. Data from 16 historical controls were used for comparison.


The mean plasma adiponectin concentration for the ICU cohort on D3 and D7 were not significantly different (4.1 ± 1.8 and 5.0 ± 3.3 mcg/ml respectively, P = 0.38). However, these were significantly lower than the mean plasma adiponectin in the control population (8.78 ± 3.81 mcg/ml) at D3 (P < 0.0001) and D7 (P = 0.002). Plasma adiponectin showed a strong correlation with plasma cortisol in the ICU group on both D3 (R2 = 0.32, P < 0.01) and D7 (R2 = 0.64, 0.001). There was an inverse correlation between plasma adiponectin and CRP on D7, R = -0.35.


In this preliminary study, critical illness was associated with lower adiponectin concentrations as compared with controls. A significant relationship between plasma cortisol and adiponectin in critically ill patients was evident, both during the early and late phases. These data raise the possibility that adiponectin may play a part in the inflammatory response in patients with severe illness.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number: R105

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Created: Sun, 13 Dec 2009, 00:06:59 EST