Influence of Altered Blood Rheology on Ventricular-Vascular Response to Exercise

Sharman, J. E., Brown, J., Holland, D. J., Macdonald, G, Kostner, K. and Marwick, T. H. (2009) Influence of Altered Blood Rheology on Ventricular-Vascular Response to Exercise. Hypertension, 54 5: 1092-1098. doi:10.1161/HYPERTENSIONAHA.109.135525

Author Sharman, J. E.
Brown, J.
Holland, D. J.
Macdonald, G
Kostner, K.
Marwick, T. H.
Title Influence of Altered Blood Rheology on Ventricular-Vascular Response to Exercise
Journal name Hypertension   Check publisher's open access policy
ISSN 0194-911X
Publication date 2009
Sub-type Article (original research)
DOI 10.1161/HYPERTENSIONAHA.109.135525
Open Access Status
Volume 54
Issue 5
Start page 1092
End page 1098
Total pages 7
Editor J. E. Hall
Place of publication United States
Publisher Lippincott Williams & Wilkins
Collection year 2010
Language eng
Subject C1
920103 Cardiovascular System and Diseases
920201 Allied Health Therapies (excl. Mental Health Services)
110201 Cardiology (incl. Cardiovascular Diseases)
Abstract Blood (or plasma) rheology is related to cardiovascular risk. Mechanisms of this association are unclear but may be partially related to impaired left ventricular (LV) function and increased central blood pressure (BP) during light activity. This study aimed to test these hypotheses. Twenty patients (14 men; aged 61 +/- 12 years) with polycythemia rubra vera (n = 16) or hemochromatosis (n = 4) were studied at rest and during exercise at approximate to 50% of maximal heart rate before and after venesection (500 mL; volume replaced with saline) to elicit an acute decrease in plasma viscosity at stable BP. Controls (n = 20) underwent the same protocol with 25-mL venesection. Central BP and augmentation index were determined by tonometry. Resting LV systolic (peak longitudinal systolic strain rate and strain) and diastolic functions were determined by tissue-Doppler echocardiography. Venesection with blood volume replacement decreased viscosity (1.46 +/- 0.10 to 1.41 +/- 0.11 centipoise), protein, and hemoglobin (P<0.05 for all) and increased strain rate and strain (P<0.001 for both) in patients but not in controls (P>0.10 for all). There was no change in LV diastolic function (P>0.12 for all). Exercise augmentation index in patients was reduced after venesection (24 +/- 12% to 17 +/- 9%; P=0.001) despite no significant change in other BP variables. Hemodynamics (resting or exercise) were not significantly changed in controls. Exercise central systolic BP correlated with triglycerides (r=0.59; P<0.001). However, neither exercise hemodynamic changes nor LV functional changes correlated with any biochemical changes after venesection (P>0.05). We conclude that an acute change in blood rheology improves ventricular-vascular interaction by enhanced LV systolic function and reduced light-exercise central BP. (Hypertension. 2009;54:1092-1098.)
Keyword blood pressure
blood viscosity
heart ventricles
Pulse-wave Velocity
Plasma-Fibrinogen level
Pressure amplification
Arterial stiffness
Augmentation index
Edinburgh artery
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 13 Dec 2009, 00:05:44 EST