Wnt signals and Frizzled activity orient anterior-posterior axon outgrowth in C. elegans

Hilliard, Massimo A. and Bargmann, Cornelia I. (2006) Wnt signals and Frizzled activity orient anterior-posterior axon outgrowth in C. elegans. Developmental Cell, 10 3: 379-390. doi:10.1016/j.devcel.2006.01.013


Author Hilliard, Massimo A.
Bargmann, Cornelia I.
Title Wnt signals and Frizzled activity orient anterior-posterior axon outgrowth in C. elegans
Journal name Developmental Cell   Check publisher's open access policy
ISSN 1534-5807
Publication date 2006-03-01
Sub-type Article (original research)
DOI 10.1016/j.devcel.2006.01.013
Volume 10
Issue 3
Start page 379
End page 390
Total pages 12
Place of publication Cambridge, Massachusetts
Publisher Cell Press
Language eng
Subject 11 Medical and Health Sciences
1103 Clinical Sciences
110320 Radiology and Organ Imaging
Abstract Secreted proteins of the Wnt family affect axon guidance, asymmetric cell division, and cell fate. We show here that C. elegans Wnts acting through Frizzled receptors can shape axon and dendrite trajectories by reversing the anterior-posterior polarity of neurons. In lin-44/Wnt and lin-17/Frizzled mutants, the polarity of the PLM mechanosensory neuron is reversed along the body axis: the long PLM process, PLM growth cone, and synapses are posterior to its cell body instead of anterior. Similarly, the polarity of the ALM mechanosensory neuron is reversed in cwn-1 egl-20 Wnt double mutants, suggesting that different Wnt signals regulate neuronal polarity at different anterior-posterior positions. LIN-17 protein is asymmetrically localized to the posterior process of PLM in a lin-44-dependent manner, indicating that Wnt signaling redistributes LIN-17 in PLM. In this context, Wnts appear to function not as instructive growth cone attractants or repellents, but as organizers of neuronal polarity.
Keyword Wnt
C. elegans Wnts
neurons
PLM
ALM
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
 
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Created: Fri, 11 Dec 2009, 12:13:07 EST by Macushla Boyle on behalf of Queensland Brain Institute