Dopaminergic neuromodulation of semantic processing: A 4-T fMRI study with levodopa

Copland, David A., McMahon, Katie L., Silburn, Peter A. and de Zubicaray, Greig I. (2009) Dopaminergic neuromodulation of semantic processing: A 4-T fMRI study with levodopa. Cerebral Cortex, 19 11: 2651-2658. doi:10.1093/cercor/bhp017


Author Copland, David A.
McMahon, Katie L.
Silburn, Peter A.
de Zubicaray, Greig I.
Title Dopaminergic neuromodulation of semantic processing: A 4-T fMRI study with levodopa
Journal name Cerebral Cortex   Check publisher's open access policy
ISSN 1047-3211
Publication date 2009-11
Year available 2009
Sub-type Article (original research)
DOI 10.1093/cercor/bhp017
Volume 19
Issue 11
Start page 2651
End page 2658
Total pages 8
Editor Pasko Rakic
Place of publication Oxford, United Kingdom.
Publisher Oxford University Press.
Collection year 2010
Language eng
Subject C1
170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
170204 Linguistic Processes (incl. Speech Production and Comprehension)
Abstract There is emerging evidence that alterations in dopaminergic transmission can influence semantic processing, yet the neural mechanisms involved are unknown. The influence of levodopa (L-DOPA) on semantic priming was investigated in healthy individuals (n = 20) using event-related functional magnetic resonance imaging with a randomized, double-blind crossover design. Critical prime-target pairs consisted of a lexical ambiguity prime and 1) a target related to the dominant meaning of the prime (e.g., bank-money), 2) a target related to the subordinate meaning (e.g., fence-sword), or 3) an unrelated target (e.g., ball-desk). Behavioral data showed that both dominant and subordinate meanings were primed on placebo. In contrast, there was preserved priming of dominant meanings and no significant priming of subordinate meanings on L-DOPA, the latter associated with decreased anterior cingulate and dorsal prefrontal cortex activity. Dominant meaning activation on L-DOPA was associated with increased activity in the left rolandic operculum and left middle temporal gyrus. These findings suggest that L-DOPA enhances frequency-based semantic focus via prefrontal and temporal modulation of automatic semantic priming and through engagement of anterior cingulate mechanisms supporting attentional/controlled priming.
Keyword Brain imaging
Dopamine
fMRI
Language
Lexical ambiguity
Semantic priming
Event-related Fmri
Parkinsons-disease
cognitive function
Ambiguous Words
Working-memory
Functional Mri
Brain Activity
Modulation
Activation
Cortex
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Thu, 10 Dec 2009, 15:19:25 EST by Ms May Balasaize on behalf of UQ Centre for Clinical Research