Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 GeV/nucleon 56Fe Ions

Weil, Michael M., Bedford, Joel S., Bielefeldt-Ohmann, Helle, Ray, F. Andrew, Genika, Paula C,, Ehrhart, Eugene J., Fallgren, Christina M., Hailu, Fitsum, Battaglia, Christine L. R., Charles, Brad, Callan, Matthew A. and Ullrich, Robert L. (2009) Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 GeV/nucleon 56Fe Ions. Radiation Research, 172 2: 213-219. doi:10.1667/RR1648.1


Author Weil, Michael M.
Bedford, Joel S.
Bielefeldt-Ohmann, Helle
Ray, F. Andrew
Genika, Paula C,
Ehrhart, Eugene J.
Fallgren, Christina M.
Hailu, Fitsum
Battaglia, Christine L. R.
Charles, Brad
Callan, Matthew A.
Ullrich, Robert L.
Title Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 GeV/nucleon 56Fe Ions
Formatted title
Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 GeV/nucleon 56Fe Ions
Journal name Radiation Research   Check publisher's open access policy
ISSN 0033-7587
1938-5404
Publication date 2009-08
Sub-type Article (original research)
DOI 10.1667/RR1648.1
Open Access Status
Volume 172
Issue 2
Start page 213
End page 219
Total pages 7
Place of publication New York , U.S.
Publisher Academic Press for Radiation Research Society
Language eng
Formatted abstract
Estimates of cancer risks posed to space-flight crews by exposure to high atomic number, high-energy (HZE) ions are subject to considerable uncertainty because epidemiological data do not exist for human populations exposed to similar radiation qualities. We assessed the leukemogenic efficacy of one such HZE species, 1 GeV 56Fe ions, a component of space radiation, in a mouse model for radiation-induced acute myeloid leukemia. CBA/CaJ mice were irradiated with 1 GeV/nucleon 56Fe ions or 137Cs γ rays and followed until they were moribund or to 800 days of age. We found that 1 GeV/nucleon 56Fe ions do not appear to be substantially more effective than γ rays for the induction of acute myeloid leukemia (AML). However, 56Fe-ion-irradiated mice had a much higher incidence of hepatocellular carcinoma (HCC) than γ-irradiated mice, with an estimated RBE of approximately 50. These data suggest a difference in the effects of HZE iron ions on the induction of leukemia compared to solid tumors, suggesting potentially different mechanisms of tumorigenesis.
Keyword Space flight crews
High atomic number
Space radiation
Leukemogenic efficacy
Radiation
Acute Myeloid Leukaemia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Veterinary Science Publications
 
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Created: Wed, 09 Dec 2009, 13:53:57 EST by Rosalind Blair on behalf of Faculty Of Nat Resources, Agric & Veterinary Sc