Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of Simian-Human Immunodeficiency Virus SF162P3

Jayaraman, Pushpa, Zhu, Tuofu, Misher, Lynda, Mohan, Deepika, Kuller, La Rene, Polacino, Patricia, Richardson, Barbra A., Bielefeldt-Ohmann, Helle, Anderson, David, Hu, Shui-Lok and Haigwood, Nancy L. (2007) Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of Simian-Human Immunodeficiency Virus SF162P3. Journal of Virology, 81 2: 822-834. doi:10.1128/JVI.01759-06


Author Jayaraman, Pushpa
Zhu, Tuofu
Misher, Lynda
Mohan, Deepika
Kuller, La Rene
Polacino, Patricia
Richardson, Barbra A.
Bielefeldt-Ohmann, Helle
Anderson, David
Hu, Shui-Lok
Haigwood, Nancy L.
Title Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of Simian-Human Immunodeficiency Virus SF162P3
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1098-5514
Publication date 2007-01-01
Year available 2007
Sub-type Article (original research)
DOI 10.1128/JVI.01759-06
Open Access Status DOI
Volume 81
Issue 2
Start page 822
End page 834
Total pages 13
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract To model human immunodeficiency virus (HIV) perinatal transmission, we studied infection of simian-human immunodeficiency virus (SHIV) SF162P3 in 10 pregnant Macaca nemestrina females and their offspring. Four of nine infants born to and suckled by these dams had evidence of infection, a transmission rate of 44.4% (95% confidence interval, 13.7% to 78.8%). We quantified transplacentally acquired and de novo Env-specific immunoglobulin G (IgG), IgM, and neutralizing antibodies in newborns. Transmission of escape variants was confirmed. In utero infection (n = 1) resulted in high viremia, depletion of peripheral CD4+ T cells, and rapid evolution of env in blood and tissues. Peripartum or postpartum SHIV infection (n = 3) resulted in postacute viral control that was undetectable by very sensitive multiplex PCR, despite increasing antibodies. Seropositive infants with highly controlled viremia had homogeneous peripheral blood env sequences, and their tissues had <3 copies per million cells. A high incidence of seropositive virus-low or -negative SHIV infection in infant macaques has implications for HIV type 1 perinatal transmission and detection.
Keyword Human immunodeficiency virus--HIV
Perinatal Transmission
Simian Immunodeficiency Virus
Macaca-nemestrina females
transplacental infection
Immunoglobulin G/analysis
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Veterinary Science Publications
 
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Created: Mon, 07 Dec 2009, 15:25:40 EST by Rosalind Blair on behalf of Faculty Of Nat Resources, Agric & Veterinary Sc