Body mass index is independently associated with inflammatory burden in patients with chronic kidney disease

Petchey, WG, Campbell, S, Van Eps, C, Mudge, D, Johnson, D, Hawley, C and Isbel, N (2009). Body mass index is independently associated with inflammatory burden in patients with chronic kidney disease. In: Nephrology. 45th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Hobart, Australia, (A29-A29). 7 - 9 September, 2009. doi:10.1111/j.1440-1797.2009.01176.x


Author Petchey, WG
Campbell, S
Van Eps, C
Mudge, D
Johnson, D
Hawley, C
Isbel, N
Title of paper Body mass index is independently associated with inflammatory burden in patients with chronic kidney disease
Conference name 45th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology
Conference location Hobart, Australia
Conference dates 7 - 9 September, 2009
Proceedings title Nephrology   Check publisher's open access policy
Journal name Nephrology   Check publisher's open access policy
Place of Publication Carlton, Australia
Publisher Wiley InterScience
Publication Year 2009
DOI 10.1111/j.1440-1797.2009.01176.x
ISSN 1320-5358
1440-1797
Volume 14
Issue Supp. 1
Start page A29
End page A29
Total pages 1
Language eng
Formatted Abstract/Summary
Aim: To assess the relationship between Body Mass Index (BMI) and C-Reactive Protein (CRP) in CKD patients.

Background: Renal physicians currently face a predicament – advising patients regarding obesity. Obesity has been associated with increased survival in the dialysis population, but its role as a protective factor in the pre-dialysis CKD population is unknown. Obesity is classically associated with a number of known cardiovascular risk factors, and as cardiovascular events are the leading cause of pre-dialysis mortality it is felt to be counter-intuitive to not advise weight loss. To add knowledge to this field, we hypothesised that obesity may correlate with a known novel cardiovascular risk factor (CRP) at baseline, and negatively predict survival over time.

Methods: Assessment of incident CKD referrals (stages 2–5) made to Princess Alexandra Hospital Renal Unit between November 2008 and March 2009.

Results: Population (n = 201); age 61.6 ± 15.2 years; 53.8% male; 33.5% diabetic and majority CKD stage 3 (stages 2–5; 17.6%, 52.7%, 23.1%, 6.6% respectively). The median BMI was 28.8 Kg/m² (15.4–62.9) with only 22.4% of patients having a BMI within the WHO normal weight range (18.5–25 Kg/m²). BMI was not associated with age, gender or eGFR. Increased BMI was associated with diabetic status (p < 0.05). CRP correlated positively with BMI (n = 125, r = 0.342; p < 0.001), particularly in morbidly obese individuals (BMI > 35 Kg/m²) who had a median CRP of 6.1 mg/L compared to 2.6 mg/L in those of normal weight, which was independent of diabetic status on multivariate analysis.

Conclusions: BMI positively correlates with CRP in the CKD population, independent of factors including diabetic status. This cohort will be followed in a longitudinal manner to assess whether baseline CRP and obesity is predictive of poorer long-term outcome.
Subjects 1103 Clinical Sciences
110312 Nephrology and Urology
Keyword Body mass index
Kidney disease
C-Reactive protein
CKD patients
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Sun, 06 Dec 2009, 00:03:02 EST