Distribution of volumes of different glomeruli within individuals: Findings in kidneys at coronial autopsy

Hoy, WE, Zimany, MA, Samuel, T, Hughson, MD, Douglas-Denton, RN, Holden, LM, Mott, SA and Bertram, JF (2009). Distribution of volumes of different glomeruli within individuals: Findings in kidneys at coronial autopsy. In: Nephrology. Abstracts of the 45th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology. 45th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Hobart, Tasmania, Australia, (A15-A15). 7–9 September 2009. doi:10.1111/j.1440-1797.2009.01176.x


Author Hoy, WE
Zimany, MA
Samuel, T
Hughson, MD
Douglas-Denton, RN
Holden, LM
Mott, SA
Bertram, JF
Title of paper Distribution of volumes of different glomeruli within individuals: Findings in kidneys at coronial autopsy
Conference name 45th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology
Conference location Hobart, Tasmania, Australia
Conference dates 7–9 September 2009
Proceedings title Nephrology. Abstracts of the 45th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology   Check publisher's open access policy
Journal name Nephrology   Check publisher's open access policy
Place of Publication Carlton North, Victoria, Australia
Publisher Wiley Interscience
Publication Year 2009
Sub-type Fully published paper
DOI 10.1111/j.1440-1797.2009.01176.x
ISSN 1320-5358
1440-1797
Volume 14 Suppl 1
Issue s1
Start page A15
End page A15
Total pages 1
Language eng
Abstract/Summary Aim: To describe the distribution of volumes of different glomeruli in individuals (IgV), and some associations. Background: Existing studies describe correlations of glomerular volume with age, with nephron number and birthweight, inversely, and with adult body size and hypertension. However, those are derived estimates of glomerular volume, and only a single value is generated per kidney. We measured the volume of multiple glomeruli without sclerosis in the right kidney of adult white males in Jackson, MS, undergoing autopsy for sudden or unexpected death. They had no gross renal abnormalities, and no documented renal disease. Methods: Volumes of 30 glomeruli, 10 from the outer, middle and inner cortical zones, were measured by the Cavalieri method. Results were evaluated by age (20–30 and 60–70 years), nephron number (top and bottom quintiles), birthweight (top and bottom quintiles), BMI (<25 and >35 kg/m2) and by hypertension, with six subjects (and 180 glomeruli) in each category. IgV and IgV variances were compared in aggregate and again, among individuals. Results: In aggregate, IgV (mean, SD) was greater with higher age, 4.0(1.3) vs 3.7(1.2), p = 0.01, lower nephron number, 6.4(0.2) vs 3.0(0.1), p ≤ 0.0001, lower birthweight, 5.2(2.1) vs 3.7(1.4), p ≤ 0.0001, higher BMI, 5.0(0.1) vs 3.5(0.1), p ≤ 0.0001, and hypertension, 4.7(0.1) vs 4.1(0.1), p = 0.0003. In groups of individuals, the differences remained significant for nephron number and BMI (p ≤ 0.001), and, marginally, for birthweight (p = 0.06). However, IgV variances were significantly larger in those of higher age (p = 0.007), lower nephron number (p = 0.007) and higher BMI, (p = 0.02), than their comparator groups. Conclusions: Hypertrophic stress, marked by greater mean glomerular volume and volume heterogeneity, is differently expressed among different glomeruli within individuals. Excessive enlargement probably marks the pathway to glomerulosclerosis.
Subjects 1102 Cardiovascular Medicine and Haematology
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Article number: 056

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Sun, 06 Dec 2009, 00:02:34 EST