Tick-susceptible Bos taurus cattle display an increased cellular response at the site of larval Rhipicephalus (Boophilus) microplus attachment, compared with tick-resistant Bos indicus cattle

Piper, Emily K., Jackson, Louise A., Bielefeldt-Ohmanna, Helle, Gondroa, Cedric, Lew-Tabora , Ala E. and Jonsson, Nicholas N. (2010) Tick-susceptible Bos taurus cattle display an increased cellular response at the site of larval Rhipicephalus (Boophilus) microplus attachment, compared with tick-resistant Bos indicus cattle. International Journal for Parasitology, 40 4: 431-441. doi:10.1016/j.ijpara.2009.09.009


Author Piper, Emily K.
Jackson, Louise A.
Bielefeldt-Ohmanna, Helle
Gondroa, Cedric
Lew-Tabora , Ala E.
Jonsson, Nicholas N.
Title Tick-susceptible Bos taurus cattle display an increased cellular response at the site of larval Rhipicephalus (Boophilus) microplus attachment, compared with tick-resistant Bos indicus cattle
Formatted title
Tick-susceptible Bos taurus cattle display an increased cellular response at the site of larval Rhipicephalus (Boophilus) microplus attachment, compared with tick-resistant Bos indicus cattle
Journal name International Journal for Parasitology   Check publisher's open access policy
ISSN 0020-7519
1879-0135
Publication date 2010-03-15
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.ijpara.2009.09.009
Volume 40
Issue 4
Start page 431
End page 441
Total pages 11
Place of publication Oxford, United Kingdom
Publisher Elsevier
Collection year 2011
Language eng
Formatted abstract
Cattle demonstrate divergent and heritable phenotypes of resistance and susceptibility to infestation with the cattle tick Rhipicephalus (Boophilus) microplus. Bos indicus cattle are generally more resistant to tick infestation than Bos taurus breeds although large variations in resistance can occur within subspecies and within breed. Increased tick resistance has been previously associated with an intense hypersensitivity response in B. taurus breeds; however, the mechanism by which highly resistant B. indicus cattle acquire and sustain high levels of tick resistance remains to be elucidated. Using the commercially available Affymetrix microarray gene expression platform, together with histological examination of the larval attachment site, this study aimed to describe those processes responsible for high levels of tick resistance in Brahman (B. indicus) cattle that differ from those in low-resistance Holstein-Friesian (B. taurus) cattle. We found that genes involved in inflammatory processes and immune responsiveness to infestation by ticks, although up-regulated in tick-infested Holstein-Friesian cattle, were not up-regulated in Brahman cattle. In contrast, genes encoding constituents of the extracellular matrix were up-regulated in Brahmans. Furthermore, the susceptible Holstein-Friesian animals displayed a much greater cellular inflammatory response at the site of larval R. microplus attachment compared with the tick-resistant Brahman cattle. © 2009 Australian Society for Parasitology Inc.
Keyword Phenotype analysis
Resistance mechanisms
Susceptibility/resistance
Rhipicephalus (Boophilus) microplus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 21 October 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Veterinary Science Publications
 
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Created: Wed, 02 Dec 2009, 15:49:34 EST by Rosalind Blair on behalf of School of Veterinary Science