Classification of physiologically significant pumping states in an implantable rotary blood pump: Effects of cardiac rhythm disturbances

Karantonis, Dean M., Lovell, Nigel H., Ayre, Peter J., Mason, David Glen and Cloherty, Shaun L. (2007) Classification of physiologically significant pumping states in an implantable rotary blood pump: Effects of cardiac rhythm disturbances. Artificial Organs, 31 6: 476-479. doi:10.1111/j.1525-1594.2007.00409.x


Author Karantonis, Dean M.
Lovell, Nigel H.
Ayre, Peter J.
Mason, David Glen
Cloherty, Shaun L.
Title Classification of physiologically significant pumping states in an implantable rotary blood pump: Effects of cardiac rhythm disturbances
Journal name Artificial Organs   Check publisher's open access policy
ISSN 0160-564X
1525-1594
Publication date 2007-06
Sub-type Article (original research)
DOI 10.1111/j.1525-1594.2007.00409.x
Volume 31
Issue 6
Start page 476
End page 479
Total pages 4
Place of publication Cambridge, United Kingdom
Publisher Blackwell Science
Language eng
Subject 0903 Biomedical Engineering
1102 Cardiovascular Medicine and Haematology
Abstract Methods of speed control for implantable rotary blood pumps (iRBPs) are vital for providing implant recipients with sufficient blood flow to cater for their physiological requirements. The detection of pumping states that reflect the physiological state of the native heart forms a major component of such a control method. Employing data from a number of acute animal experiments, five such pumping states have been previously identified: regurgitant pump flow, ventricular ejection (VE), nonopening of the aortic valve (ANO), and partial collapse (intermittent [PVC-I] and continuous [PVC-C]) of the ventricle wall.An automated approach that noninvasively detects such pumping states, employing a classification and regression tree (CART), has also been developed.An extension to this technique, involving an investigation into the effects of cardiac rhythm disturbances on the state detection process, is discussed. When incorporating animal data containing arrhythmic events into the CART model, the strategy showed a marked improvement in detecting pumping states as compared to the model devoid of arrhythmic data: state VE—57.4/91.7% (sensitivity/specificity) improved to 97.1/100.0%; state PVC-I—66.7/83.1% improved to 100.0/ 88.3%, and state PVC-C—11.1/66.2% changed to 0.0/ 100%. With a simplified binary scheme differentiating suction (PVC-I,PVC-C) and nonsuction (VE,ANO) states, suction was initially detected with 100/98.5% sensitivity/ specificity, whereas with the subsequent improved model, both these states were detected with 100% sensitivity. The accuracy achieved demonstrates the robustness of the technique presented, and substantiates its inclusion into any iRBP control methodology.
Keyword Implantable rotary blood pumps
Cardiac rhythm
Pumping states
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 7 May 2007.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Information Technology and Electrical Engineering Publications
 
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