Modifications of drug metabolism by disulfiram and diethyldithiocarbamate II. d-glucuronic acid pathway

Marselos, Marios, Lang, Matti and Torronen, Riitta (1976) Modifications of drug metabolism by disulfiram and diethyldithiocarbamate II. d-glucuronic acid pathway. Chemico-Biological Interactions, 15 3: 277-287. doi:10.1016/0009-2797(76)90153-8


Author Marselos, Marios
Lang, Matti
Torronen, Riitta
Title Modifications of drug metabolism by disulfiram and diethyldithiocarbamate II. d-glucuronic acid pathway
Journal name Chemico-Biological Interactions   Check publisher's open access policy
ISSN 0009-2797
1872-7786
Publication date 1976-11-01
Sub-type Article (original research)
DOI 10.1016/0009-2797(76)90153-8
Volume 15
Issue 3
Start page 277
End page 287
Total pages 11
Place of publication Shannon, Ireland
Publisher Elsevier, Ireland
Language eng
Abstract Hepatic enzymes connected with the formation and metabolism of free d-glucuronic acid were affected in rats after treatment with disulfiram or diethyldithiocarbamate (300 mg/kg, intragastrically, per day, 4 X). The activities of UDPglucose dehydrogenase, UDPglucuronic acid pyrophosphatase, UDPglucuronosyltransferase and l-gulonate dehydrogenase were enhanced, while those of glucose-6-phosphate dehydrogenase, β-glucuronidase and d-glucuronolactone dehydrogenase were inhibited. These changes were more pronounced with disulfiram than diethyldithiocarbamate. Treatment with phenobarbital (80 mg/kg, i.p., per day, 4 X) enhanced UDP glucuronosyltransferase, but brought about different effects on the other enzymes. Concurrent administration of phenobarbital with disulfiram or diethyldithiocarbamate led to potentiation or antagonism of the primary effects of each compound when given alone. The results suggest that activation of the d-glucuronic acid pathway may proceed in various ways, and that it is not necessarily followed by a simultaneous induction of the microsomal mixed-function oxygenase activity.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
 
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Created: Tue, 01 Dec 2009, 01:06:34 EST