Depression of drug metabolism in liver microsomes after treating rats with unsaturated fatty acids

Lang, Matti (1976) Depression of drug metabolism in liver microsomes after treating rats with unsaturated fatty acids. General Pharmacology, 7 6: 415-419.


Author Lang, Matti
Title Depression of drug metabolism in liver microsomes after treating rats with unsaturated fatty acids
Journal name General Pharmacology   Check publisher's open access policy
ISSN 0306-3623
Publication date 1976
Sub-type Article (original research)
DOI 10.1016/0306-3623(76)90008-2
Volume 7
Issue 6
Start page 415
End page 419
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract 1. Elaidic and linoleic acids were administered to rats intraperitoneally at dose levels of 40 and 200 mg/kg during 5 weeks. Fattyacids had a tendency to decrease both the amount of protein and phospholipids in livermicrosomes. Also the fattyacid composition of the microsomal phospholipids was modified by the fattyacids.

2. Microsomal aryl hydrocarbon hydroxylase and p-nitroanisole-O-demethylase activities were lowered by linoleic acid. The decrease in the enzyme activities was, however, not identical. Also elaidic acid tended to decrease the activity of these enzymes. In addition, a slight decrease in microsomal cytochrome P-450 content and in the activity of NADPH cytochrome c reductase took place.

3. The activity of microsomal UDPglucuronosyltransferase was significantly decreased by both of the fattyacids.

4. The results suggest that unsaturatedfattyacids affect the activities of microsomal drug metabolizing enzymes at least partly by modifying the membrane structure.

5. It seems that the effects are substrate specific and to some extent opposite to those of dietary unsaturated triglycerides and cholesterol.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Journal continues Vascular Pharmacology (1537-1891)

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
 
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