Enhancement of hepatic drug biotransformation rate by polychlorinated biphenyls in rats fed cholesterol-rich diet

Laitinen, Matti, Lang, Matti A., Hietanen, Eino and Vainio, Harri (1975) Enhancement of hepatic drug biotransformation rate by polychlorinated biphenyls in rats fed cholesterol-rich diet. Toxicology, 5 1: 79-88. doi:10.1016/0300-483X(75)90072-4


Author Laitinen, Matti
Lang, Matti A.
Hietanen, Eino
Vainio, Harri
Title Enhancement of hepatic drug biotransformation rate by polychlorinated biphenyls in rats fed cholesterol-rich diet
Journal name Toxicology   Check publisher's open access policy
ISSN 0300-483X
1879-3185
Publication date 1975-09
Sub-type Article (original research)
DOI 10.1016/0300-483X(75)90072-4
Volume 5
Issue 1
Start page 79
End page 88
Total pages 10
Place of publication Shannon, Ireland
Publisher Elsevier Ireland
Language eng
Abstract A combined effect of cholesterol and polychlorinated biphenyls (PCBs) on the microsomal drug hydroxylation and glucuronidation in the liver of the rat was studied. PCBs, Clophen A-50 and A-60, having an average chlorination degree of 50 and 60% affect the structure of microsomal membranes. It was found that Clophen A-60 increased the binding of trypsin- and digitonin-sensitive proteins to the membranes. Also it was found that PCBs enhanced the phospholipid content of microsomes. PCBs increased the activity of hepatic NADPH cytochrome c reductase about 1.5-fold. Aryl hydrocarbon hydroxylase activity doubled with Clophen A-50 and quadrupled with Clophen A-60. Hepatic UDPglucuronosyltransferase activity was doubled with both PCBs. The enhancement in hepatic aryl hydrocarbon hydroxylase and in UDPglucuronosyntransferase was found to be lower in the presence of high cholesterol level in the diet when compared to earlier results. This is supposed to be due to the membraneous effects of cholesterol.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
 
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Created: Mon, 30 Nov 2009, 15:05:17 EST