Stress modulates the enzymatic inducibility by benzo[alpha]pyrene in the rat liver

Konstandi, Maria, Johnson, Elizabeth, Lang, Matti A., Camus-Radon, Anne Marie and Marselos, Marios (2000) Stress modulates the enzymatic inducibility by benzo[alpha]pyrene in the rat liver. Pharmacological Research, 42 3: 205-211. doi:10.1006/phrs.2000.0675

Author Konstandi, Maria
Johnson, Elizabeth
Lang, Matti A.
Camus-Radon, Anne Marie
Marselos, Marios
Title Stress modulates the enzymatic inducibility by benzo[alpha]pyrene in the rat liver
Formatted title
Stress modulates the enzymatic inducibility by benzo[α]pyrene in the rat liver
Journal name Pharmacological Research   Check publisher's open access policy
ISSN 1043-6618
Publication date 2000-09
Sub-type Article (original research)
DOI 10.1006/phrs.2000.0675
Volume 42
Issue 3
Start page 205
End page 211
Total pages 7
Place of publication London, United Kingdom
Publisher Academic Press
Language eng
Abstract The role of stress on the inducibility by benzo[ α ]pyrene (B[ α ]P), a representative polycyclic aromatic hydrocarbon, of several drug-metabolizing enzymes was investigated in rats, using restraint stress and mild unpredictable stress as models of psychological stress. Restraint stress was found to significantly suppress basal ethoxyresorufin 7-dealkylase (EROD) and pentoxyresorufin 7-dealkylase (PROD) activities (two-fold). In contrast, mild unpredictable stress markedly increased basal EROD activity, while PROD activity was not affected. In addition, both types of stress resulted in a significant reduction of basal p -nitrophenol hydroxylation (PNP). It is worth noting that restraint stress greatly enhanced the inducibility of EROD, methoxyresorufin 7-dealkylase (MROD) and to a lesser extent PROD activities by B[ α ]P, while mild unpredictable stress had no, or only a mild effect on the inducibility of cytochrome P450s (CYPs) by B[ α ]P. In conclusion, psychological stress may modulate different enzymatic systems which are vital elements of the detoxification mechanisms of the body. The two distinct types of psychological stress used in this study appear to affect the enzymatic systems under investigation in a stress-specific manner at the basal level and at the induced state by B[ α ]P.
Keyword Stress
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
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Created: Mon, 30 Nov 2009, 15:04:11 EST