Coumarin 7-hydroxylase in inbred strains of mice: Comparison with other microsomal monooxygenase activities and induction by pyrazole

Juvonen, R., Kaipainen, P., Hanninen, O. and Lang, M. (1986) Coumarin 7-hydroxylase in inbred strains of mice: Comparison with other microsomal monooxygenase activities and induction by pyrazole. Archives of Toxicology, 59 Suppl. 9: 367-370.

Author Juvonen, R.
Kaipainen, P.
Hanninen, O.
Lang, M.
Title Coumarin 7-hydroxylase in inbred strains of mice: Comparison with other microsomal monooxygenase activities and induction by pyrazole
Journal name Archives of Toxicology   Check publisher's open access policy
ISSN 0340-5761
1432-0738
Publication date 1986
Sub-type Article (original research)
Volume 59
Issue Suppl. 9
Start page 367
End page 370
Total pages 4
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract This study was carried out in order to find out the effects of pyrazole on liver drug metabolism in several inbred mice: D2, B6, BALB, and AKR and in the outbred mouse NMRI. Compared to control pyrazole treatment decreased the microsomal cytochrome P-450 content of liver to 60-70% and benzo(a)pyrene hydroxylase and ethylmorphine N-demethylase activities to 40-55% and increased 7-ethoxycoumarin O-deethylase activity to 100-200% in AKR, BALB, B6, and NMRI mice and 300% in D2 mouse. Coumarin 7-hydroxylase was increased only 200-300% in B6, AKR, and BALB mice and as much as 700% in D2 and 900% in NMRI mice compared to control. Coumarin 7-hydroxylase is under different genetic control from other monooxygenase activities and differently expressed in various strains of mice.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
 
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