Expression profiling identifies genes involved in neoplastic transformation of serous ovarian cancer

Merritt, Melissa A., Parsons, Peter G., Newton, Tanya R., Martyn, Adam C., Webb, Penlope M., Green, Adele C., Papadimos, David J. and Boyle, Glen M. (2009) Expression profiling identifies genes involved in neoplastic transformation of serous ovarian cancer. BMC Cancer, 9 378.1-378.13. doi:10.1186/1471-2407-9-378

Author Merritt, Melissa A.
Parsons, Peter G.
Newton, Tanya R.
Martyn, Adam C.
Webb, Penlope M.
Green, Adele C.
Papadimos, David J.
Boyle, Glen M.
Title Expression profiling identifies genes involved in neoplastic transformation of serous ovarian cancer
Journal name BMC Cancer   Check publisher's open access policy
ISSN 1471-2407
Publication date 2009-10
Sub-type Article (original research)
DOI 10.1186/1471-2407-9-378
Open Access Status DOI
Volume 9
Start page 378.1
End page 378.13
Total pages 13
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2010
Language eng
Formatted abstract
The malignant potential of serous ovarian tumors, the most common ovarian tumor subtype, varies from benign to low malignant potential (LMP) tumors to frankly invasive cancers. Given the uncertainty about the relationship between these different forms, we compared their patterns of gene expression.
Expression profiling was carried out on samples of 7 benign, 7 LMP and 28 invasive (moderate and poorly differentiated) serous tumors and four whole normal ovaries using oligonucleotide microarrays representing over 21,000 genes.
We identified 311 transcripts that distinguished invasive from benign tumors, and 20 transcripts that were significantly differentially expressed between invasive and LMP tumors at p < 0.01 (with multiple testing correction). Five genes that were differentially expressed between invasive and either benign or normal tissues were validated by real time PCR in an independent panel of 46 serous tumors (4 benign, 7 LMP, 35 invasive). Overexpression of SLPI and WNT7A and down-regulation of C6orf31, PDGFRA and GLTSCR2 were measured in invasive and LMP compared with benign and normal tissues. Over-expression of WNT7A in an ovarian cancer cell line led to increased migration and invasive capacity.
These results highlight several genes that may play an important role across the spectrum of serous ovarian tumorigenesis.
Keyword Suppressor candidate protein
Molecular Markers
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number 378

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Public Health Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 29 Nov 2009, 00:05:25 EST