Reducible disulfide-based non-viral gene delivery systems

Ouyang, D., Shah, N., Zhang, H, Smith, S. C. and Parekh, H. S. (2009) Reducible disulfide-based non-viral gene delivery systems. Mini-Reviews in Medicinal Chemistry, 9 10: 1242-1250. doi:10.2174/138955709789055225

Author Ouyang, D.
Shah, N.
Zhang, H
Smith, S. C.
Parekh, H. S.
Title Reducible disulfide-based non-viral gene delivery systems
Journal name Mini-Reviews in Medicinal Chemistry   Check publisher's open access policy
ISSN 1389-5575
Publication date 2009
Year available 2009
Sub-type Article (original research)
DOI 10.2174/138955709789055225
Volume 9
Issue 10
Start page 1242
End page 1250
Total pages 9
Editor Krapcho, A. P.
Rahman, A.
Choudhary, M. I.
Talaga, P.
Place of publication Netherlands
Publisher Bentham Science Publishers Ltd.
Collection year 2010
Language eng
Subject C1
030503 Organic Chemical Synthesis
030405 Molecular Medicine
060199 Biochemistry and Cell Biology not elsewhere classified
110105 Medical Biochemistry: Nucleic Acids
111504 Pharmaceutical Sciences
920102 Cancer and Related Disorders
920112 Neurodegenerative Disorders Related to Ageing
920110 Inherited Diseases (incl. Gene Therapy)
970103 Expanding Knowledge in the Chemical Sciences
970111 Expanding Knowledge in the Medical and Health Sciences
Abstract The design and synthesis of safe efficient non-viral vectors for gene delivery has attracted significant attention in recent years due primarily to the severe side-effect profile reported with the use of their viral counterparts. Previous experiments have revealed that the strong interaction between the carriers and nucleic acid may well hinder the release of the gene from the complex in the cytosol adversely affecting transfection efficiency. However, incorporating reducible disulfide bonds within the delivery systems themselves which are then cleaved in the glutathione-rich intracellular environment may help in solving this puzzle. This review focuses on recent development of these reducible carriers. The biological rationale and approaches to the synthesis of reducible vectors are discussed in detail. The in vitro and in vivo evaluations of reducible carriers are also summarized and it is evident that they offer a promising approach in non-viral gene delivery system design.
Keyword Disulphide bond
reducible vector
non-viral vector
gene delivery
Q-Index Code C1
Q-Index Status Confirmed Code

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Created: Sun, 29 Nov 2009, 00:02:07 EST