The relationship between age, injury severity and MRI findings following traumatic brain injury

Schonberger, Michael, Ponsford, Jennie, Reutens, David, Beare, Richard and O'Sullivan, Richard (2009) The relationship between age, injury severity and MRI findings following traumatic brain injury. Journal of Neurotrauma, 26 12: 2157-2167. doi:10.1089/neu.2009.0939


Author Schonberger, Michael
Ponsford, Jennie
Reutens, David
Beare, Richard
O'Sullivan, Richard
Title The relationship between age, injury severity and MRI findings following traumatic brain injury
Journal name Journal of Neurotrauma   Check publisher's open access policy
ISSN 0897-7151
1557-9042
Publication date 2009-12
Sub-type Article (original research)
DOI 10.1089/neu.2009.0939
Volume 26
Issue 12
Start page 2157
End page 2167
Total pages 11
Editor Dr. John T Povlishock
Place of publication New York, NY, United States
Publisher Mary Ann Liebert
Collection year 2010
Language eng
Subject 11 Medical and Health Sciences
1109 Neurosciences
C1
Abstract Age and injury severity are amongst the most significant predictors of outcome after Traumatic Brain Injury (TBI). However, only a few studies have investigated the association between, age, injury severity and the extent of brain damage in TBI. The purpose of this study was to investigate the association between age, measures of injury severity and brain lesion volumes as well as viable brain volumes following TBI. Ninety-eight individuals with mild to very severe TBI (75.5% male, mean age at injury 34.5 years) underwent a structural MRI scan, performed with a 1.5 Tesla machine, on average 2.3 years post-injury. Lesion volumes were highly skewed in their distribution and were dichotomized for statistical purposes. Measures of injury severity were Glasgow Coma Scale (GCS) and duration of post-traumatic amnesia (PTA). Logistic regression analyses predicting lesion volumes, controlling for participants’ sex, cause of injury, time from injury to MRI scan and total brain volume, revealed that both older age and longer PTA were associated with larger lesion volumes in both grey and white matter in almost all brain regions. Older age was also associated with smaller viable grey matter volumes in most neo-cortical brain regions, while longer PTA was associated with smaller viable white matter volumes in most brain regions. The results suggest that older age worsens the impact of TBI on the brain. They also indicate the validity of duration of PTA as a measure of injury severity that is not just related to one particular injury location.
Keyword Age
Aging
Traumatic brain injury
Magnetic resonance imaging
Brain and lesion volumes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Fri, 27 Nov 2009, 10:14:06 EST by Rosalind Blair on behalf of Centre For Magnetic Resonance