Body composition and muscle strength as predictors of bone mineral density in Crohn's disease

Lee, Naomi, Radford-Smith, Graham L., Forwood, Mark, Wong, Joseph and Taaffe, Dennis R. (2009) Body composition and muscle strength as predictors of bone mineral density in Crohn's disease. Journal of Bone and Mineral Metabolism, 27 4: 456-463. doi:10.1007/s00774-009-0059-5


Author Lee, Naomi
Radford-Smith, Graham L.
Forwood, Mark
Wong, Joseph
Taaffe, Dennis R.
Title Body composition and muscle strength as predictors of bone mineral density in Crohn's disease
Journal name Journal of Bone and Mineral Metabolism   Check publisher's open access policy
ISSN 0914-8779
1435-5604
Publication date 2009-03-31
Sub-type Article (original research)
DOI 10.1007/s00774-009-0059-5
Volume 27
Issue 4
Start page 456
End page 463
Total pages 8
Editor Y. Seino
Place of publication Tokyo
Publisher Springer Japan KK
Collection year 2010
Language eng
Subject C1
110602 Exercise Physiology
920116 Skeletal System and Disorders (incl. Arthritis)
Abstract Compromised skeletal status is a frequent finding in patients with Crohn’s disease (CD), leading to increased fracture risk. Low body weight is associated with bone mineral density (BMD) in CD, although the relative importance of its components, lean and fat mass, is unclear. Muscle strength is also a predictor of BMD in nondiseased populations; however, its association with bone in CD is unknown. We examined the independent effects of body composition and muscle strength on regional and whole-body BMD in a cohort of CD patients. Sixty men and women, aged 22–72 years, with disease duration of 13 ± 7 years, underwent scanning of the spine, hip, forearm, and whole-body BMD by dual-energy X-ray absorptiometry (DXA). Lean tissue, appendicular muscle mass (AMM), and fat mass were derived by DXA and grip strength by dynamometry. Medical history, medication usage, clinical variables, and nutritional intake were obtained by questionnaire. Prevalence of osteopenia and osteoporosis was 32 and 17%, respectively, with osteopenia more common at the hip and osteoporosis more common at the spine. In multiple regression analyses, AMM was an independent predictor of whole-body and regional BMD whereas lean mass was an independent predictor at the hip. Neither grip strength nor fat mass was independently associated with BMD. Of the components of body composition, muscle mass was strongly associated with regional and whole-body BMD. Preserving or augmenting muscle mass in this population may be a useful strategy to preserve BMD and thereby reduce fracture risk.
Keyword Crohn’s disease
Muscle mass
Fat mass
BMD
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Wed, 25 Nov 2009, 11:43:53 EST by Deborah Noon on behalf of School of Human Movement Studies