Astaxanthin, oxidative stress, inflammation and cardiovascular disease

Fassett, Robert G. and Coombes, Jeff S. (2009) Astaxanthin, oxidative stress, inflammation and cardiovascular disease. Future Cardiology, 5 4: 333-342. doi:10.2217/fca.09.19

Author Fassett, Robert G.
Coombes, Jeff S.
Title Astaxanthin, oxidative stress, inflammation and cardiovascular disease
Journal name Future Cardiology   Check publisher's open access policy
ISSN 1479-6678
Publication date 2009
Sub-type Article (original research)
DOI 10.2217/fca.09.19
Volume 5
Issue 4
Start page 333
End page 342
Total pages 10
Editor T. Greenberg
E. Manzotti
Place of publication London
Publisher Future Medicine Ltd
Collection year 2010
Language eng
Subject 1102 Cardiovascular Medicine and Haematology
920103 Cardiovascular System and Diseases
Abstract It is accepted that oxidative stress and inflammation play an integral role in the pathophysiology of many chronic diseases including atherosclerotic cardiovascular disease. The xanthophyll carotenoid dietary supplement astaxanthin has demonstrated potential as an antioxidant and anti-inflammatory therapeutic agent in models of cardiovascular disease. There have been at least eight clinical studies conducted in over 180 humans using astaxanthin to assess its safety, bioavailability and clinical aspects relevant to oxidative stress, inflammation or the cardiovascular system. There have been no adverse outcomes reported. Studies have demonstrated reduced markers of oxidative stress and inflammation and improved blood rheology. A larger number of experimental studies have been performed using astaxanthin. In particular, studies in a variety of animals using a model of myocardial ischemia and reperfusion have demonstrated protective effects from prior administration of astaxanthin both intravenously and orally. Future clinical studies and trials will help determine the efficacy of antioxidants such as astaxanthin on vascular structure, function, oxidative stress and inflammation in a variety of patients at risk of, or with, established cardiovascular disease. These may lead to large intervention trials assessing cardiovascular morbidity and mortality.
Keyword antioxidants
cardiovascular disease
xanthophyll carotenoids
Q-Index Code C1
Q-Index Status Confirmed Code

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Created: Tue, 24 Nov 2009, 18:02:35 EST by Deborah Noon on behalf of School of Human Movement and Nutrition Sciences