Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients: An observational study

Fassett, Robert G., Driver, Ritza, Healy, Helen, Ranganathan, Dwarakanathan, Ratanjee, Sharad, Robertson, Iain K., Geraghty, Dominic P., Sharman, James E. and Coombes, Jeff S. (2009) Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients: An observational study. BMC Nephrology, 10 Article No 8: xx-xx. doi:10.1186/1471-2369-10-8


Author Fassett, Robert G.
Driver, Ritza
Healy, Helen
Ranganathan, Dwarakanathan
Ratanjee, Sharad
Robertson, Iain K.
Geraghty, Dominic P.
Sharman, James E.
Coombes, Jeff S.
Title Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients: An observational study
Journal name BMC Nephrology   Check publisher's open access policy
ISSN 1471-2369
Publication date 2009-03-12
Sub-type Article (original research)
DOI 10.1186/1471-2369-10-8
Open Access Status DOI
Volume 10
Issue Article No 8
Start page xx
End page xx
Total pages 7
Place of publication London
Publisher BioMed Central
Collection year 2010
Language eng
Subject C1
110312 Nephrology and Urology
920103 Cardiovascular System and Diseases
1102 Cardiovascular Medicine and Haematology
Formatted abstract
Background: Patients on peritoneal and hemodialysis have accelerated atherosclerosis associated with an increase in cardiovascular morbidity and mortality. The atherosclerosis is associated with increased arterial stiffness, endothelial dysfunction and elevated oxidative stress and inflammation. The aims of this study are to investigate the effects of peritoneal and hemodialysis on arterial stiffness, vascular function, myocardial structure and function, oxidative stress and inflammation in incident patients with end stage kidney disease.

Methods:
This is an observational study. Eighty stage five CKD patients will be enrolled and followed for one-year. Primary outcome measures will be changes in 1) arterial stiffness measured by aortic pulse wave velocity, 2) oxidative stress assessed by plasma F-2 isoprostanes and 3) inflammation measured by plasma pentraxin-3. Secondary outcomes will include additional measures of oxidative stress and inflammation, changes in vascular function assessed using the brachial artery reactivity technique, carotid artery intimal medial thickness, augmentation index and trans thoracic echocardiography to assess left ventricular geometry, and systolic and diastolic function. Patients will undergo these measures at baseline (6-8 weeks prior to starting dialysis therapy), then at six and 12 months after starting dialysis.

Discussion:
The results of this study may guide the choice of dialysis modality in the first year of treatment. It may also lead to a larger study prospectively assessing the effect of dialysis modality on cardiovascular morbidity and mortality.
Keyword Chronic kidney-disease
Low-density lipoproteins
Renal-transplant recipients
Intima-media thickness
Central blood-pressure
Pulse-wave analysis
Technical considerations
Cardiovascular-disease
Risk
Exercise
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Tue, 24 Nov 2009, 16:11:13 EST by Deborah Noon on behalf of School of Human Movement and Nutrition Sciences