Androgen Receptor and Caveolin-1 in Prostate Cancer

Bennett, Nigel, Hooper, John D., Lee, C. Soon and Gobe, Glenda C. (2009) Androgen Receptor and Caveolin-1 in Prostate Cancer. IUBMB Life, 61 10: 961-970. doi:10.1002/IUB.244


Author Bennett, Nigel
Hooper, John D.
Lee, C. Soon
Gobe, Glenda C.
Title Androgen Receptor and Caveolin-1 in Prostate Cancer
Journal name IUBMB Life   Check publisher's open access policy
ISSN 1521-6543
1521-6551
Publication date 2009-10
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/IUB.244
Open Access Status
Volume 61
Issue 10
Start page 961
End page 970
Total pages 11
Place of publication London, UK
Publisher Taylor & Francis Group
Collection year 2010
Language eng
Subject 0601 Biochemistry and Cell Biology
C1
920102 Cancer and Related Disorders
Abstract The androgen receptor (AR) is involved in the development and maintenance of the normal prostate and the development and progression of prostate cancer (PCa). Caveolin-1 (cav-1) is an AR co-regulator. The expression of this integral membrane protein is upregulated in PCa and correlates positively with its development. This review focuses on the likely interactive roles of AR and cav-1, with particular reference to progression to androgen-insensitivity in PCa. The classical role of AR is modulation of gene transcription by binding specific DNA sequences called androgen response elements in the promoter regions of target genes. To carry out this role, AR interacts with many co-regulator proteins which either enhance or repress its activation. Altered expression or misregulated activation of a co-regulator protein may significantly alter AR activity and the basal transcription rate of androgen responsive genes. Cav-1 has roles in cell signalling and trafficking, roles that are important in PCa survival, metastasis, and the development of multidrug resistant phenotypes. Although cav-1 appears to increase AR genomic activity and increase tumor cell survival, there is also mounting evidence that cav-1 can manipulate rapid, non-genomic AR signalling at the plasma membrane. By increasing our understanding of cav-1 as an AR co-regulator, we may be able to reinstate appropriate transcriptional responses to androgen signalling and minimise misregulated AR activity, thus permitting more effective targeted therapies for PCa. © 2009 IUBMB IUBMB Life, 61(10): 961-970, 2009
Keyword androgen receptor
caveolin-1
caveolae
prostate cancer
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Mon, 23 Nov 2009, 15:26:39 EST