ABC transporters: A riddle wrapped in a mystery inside an enigma

Jones, Peter M., O'Mara, Megan L. and George, Anthony M. (2009) ABC transporters: A riddle wrapped in a mystery inside an enigma. Trends in Biochemical Sciences, 34 10: 520-531.


Author Jones, Peter M.
O'Mara, Megan L.
George, Anthony M.
Title ABC transporters: A riddle wrapped in a mystery inside an enigma
Journal name Trends in Biochemical Sciences   Check publisher's open access policy
ISSN 0968-0004
Publication date 2009-09-11
Sub-type Article (original research)
DOI 10.1016/j.tibs.2009.06.004
Volume 34
Issue 10
Start page 520
End page 531
Total pages 12
Place of publication United Kingdom
Publisher Elsevier Ltd., Trends Journals
Collection year 2010
Language eng
Subject C1
030406 Proteins and Peptides
970111 Expanding Knowledge in the Medical and Health Sciences
Abstract ATP-binding cassette (ABC) transporters form one of the largest and most ancient of protein families. ABC transporters couple hydrolysis of ATP to vectorial translocation of diverse substrates across cellular membranes. Many human ABC transporters are medically important in causing, for example, multidrug resistance to cytotoxic drugs. Seven complete prokaryotic structures and one eukaryotic structure have been solved for transporters from 2002 to date, and a wealth of research is being conducted on and around these structures to resolve the mechanistic conundrum of how these transporters couple ATP hydrolysis in cytosolic domains to substrate translocation through the transmembrane pore. Many questions remained unanswered about this mechanism, despite a plethora of data and a number of interesting and controversial models.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
 
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Created: Mon, 23 Nov 2009, 15:25:52 EST