Absence of fetal cell microchimerism in cutaneous lesions of lupus erythematosus

Khosrotehrani, K., Mery, L., Aractingi, S., Bianchi, D. W. and Johnson, K. L. (2005) Absence of fetal cell microchimerism in cutaneous lesions of lupus erythematosus. Annals of the Rheumatic Diseases, 64 1: 159-160.


Author Khosrotehrani, K.
Mery, L.
Aractingi, S.
Bianchi, D. W.
Johnson, K. L.
Title Absence of fetal cell microchimerism in cutaneous lesions of lupus erythematosus
Journal name Annals of the Rheumatic Diseases   Check publisher's open access policy
ISSN 0003-4967
Publication date 2005-01
Sub-type Article (original research)
DOI 10.1136/ard.2003.020297
Volume 64
Issue 1
Start page 159
End page 160
Total pages 2
Place of publication London
Publisher BMJ
Language eng
Subject 1107 Immunology
111401 Foetal Development and Medicine
111402 Obstetrics and Gynaecology
Abstract Fetal cell microchimerism develops in all human pregnancies and has been associated with autoimmune diseases such as systemic sclerosis. It has been suggested that these disorders may be the consequence of an immune reaction between fetal and maternal cells in women after pregnancy. More recently, results from our laboratory suggest that microchimeric cells of fetal origin may differentiate into thyrocytes or hepatocytes in thyroid and liver specimens from women with non-autoimmune diseases. We therefore developed an alternative hypothesis suggesting that microchimeric stem cells may have the ability to participate in the maternal response to tissue injury.
Keyword Sysematic lupus erythematosus
Microchimerism
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
UQ Centre for Clinical Research Publications
 
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